Human Neuron Core

Enabling drug screens for brain disorders with patient derived neurons

Boston Children’s Hospital’s Human Neuron Core offers a new paradigm for disease modeling and preclinical drug screening informed by broad expertise at Harvard in neuroscience, neurology and stem cell biology. Generous funding from the Massachusetts Life Sciences Center has enabled us to significantly expand our equipment and services and open them to the broader research community. Services fall in two main categories:

  • The Human Neuron Differentiation and Phenotyping Service provides well-characterized human neurons to academic investigators and industry collaborators to support translational research programs.
  • The expanded Assay Development Screening Facility provides multiple live-cell screening platforms that can assess image- and activity-based measures of live neurons in a medium/high-throughput capacity.

Drug Screening Services Provides A New Paradigm For Brain Disorders

To treat brain disorders in patients, we need to test drugs on brain cells made from patient stem cells.

 Patient consent & sample collection 

 Induced pluripotent stem cells

Stem Cell
Culture

Neuron
Differentiation

Neuron
Phenotyping

Equipment
Access

Assay Development
& Screening

Services offered by the human neuron differentiation and phenotyping service

  • Multi-electrode arrway (MEA)
  • Targeted RNA sequencing gene panels 
  • Assay development and screening facility
  • Hamamatsu Functional Drug Screening System
  • High content screening with live cell imaging
  • Robotics and liquid handlers

Learn more about our services