My research interests include a commitment to the assessment of outcomes in our pediatric and adult congenital cardiac patients. This encompasses ways to improve care for patients undergoing cardiac and non-cardiac surgery. In addition, I maintain an interest in large data, and the methodology to improve data quality in large data sets.


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  1. Choi RS, DiNardo JA, Brown ML. Superior Cavopulmonary Connection: Its Physiology, Limitations, and Anesthetic Implications. Semin Cardiothorac Vasc Anesth. 2020 Jul 09; 1089253220939361. View abstract
  2. Lee Y, Banooni A, Yuki K, Staffa SJ, DiNardo JA, Brown ML. Incidence and predictors of postoperative nausea and vomiting in children undergoing electrophysiology ablation procedures. Paediatr Anaesth. 2020 02; 30(2):147-152. View abstract
  3. Roy N, Parra MF, Brown ML, Sleeper LA, Nathan M, Sefton BA, Baird CW, Mistry KP, Del Nido PJ. Initial experience introducing an enhanced recovery program in congenital cardiac surgery. J Thorac Cardiovasc Surg. 2019 Oct 24. View abstract
  4. Brown ML, DiNardo JA, Nasr VG. Anesthesia in Pediatric Patients With Congenital Heart Disease Undergoing Noncardiac Surgery: Defining the Risk. J Cardiothorac Vasc Anesth. 2020 Feb; 34(2):470-478. View abstract
  5. Brown ML, Fynn-Thompson F. Commentary: Between the devil and the deep blue sea: A new palliation for high-risk neonates with hypoplastic left heart syndrome. J Thorac Cardiovasc Surg. 2019 08; 158(2):e65-e66. View abstract
  6. Sokoliuk V, DiNardo JA, Brown ML. Never Say Never: The Use of Nitric Oxide in Patients With Obstructed Pulmonary Veins: A Case Report. A A Pract. 2019 Mar 15; 12(6):205-207. View abstract
  7. Stein ML, Quinonez LG, DiNardo JA, Brown ML. Complications of Transthoracic Intracardiac and Central Venous Lines in Neonates Undergoing Cardiac Surgery. Pediatr Cardiol. 2019 Apr; 40(4):733-737. View abstract
  8. Brown ML, Nasr VG, Toohey R, DiNardo JA. Williams Syndrome and Anesthesia for Non-cardiac Surgery: High Risk Can Be Mitigated with Appropriate Planning. Pediatr Cardiol. 2018 Aug; 39(6):1123-1128. View abstract
  9. Downey L, Brown ML, Faraoni D, Zurakowski D, DiNardo JA. Recombinant Factor VIIa Is Associated With Increased Thrombotic Complications in Pediatric Cardiac Surgery Patients. Anesth Analg. 2017 05; 124(5):1431-1436. View abstract
  10. Jochman JD, Atkinson DB, Quinonez LG, Brown ML. Twenty Years of Anesthetic and Perioperative Management of Patients With Tetralogy of Fallot With Absent Pulmonary Valve. J Cardiothorac Vasc Anesth. 2017 Jun; 31(3):918-921. View abstract
  11. Brown ML. Can't you just pull the data? The limitations of using of the electronic medical record for research. Paediatr Anaesth. 2016 Nov; 26(11):1034-1035. View abstract
  12. Faraoni D, Zurakowski D, Vo D, Goobie SM, Yuki K, Brown ML, DiNardo JA. Post-Operative Outcomes in Children With and Without Congenital Heart Disease Undergoing Noncardiac Surgery. J Am Coll Cardiol. 2016 Feb 23; 67(7):793-801. View abstract
  13. Brown ML, DiNardo JA, Odegard KC. Patients with single ventricle physiology undergoing noncardiac surgery are at high risk for adverse events. Paediatr Anaesth. 2015 Aug; 25(8):846-851. View abstract
  14. Brown ML, Burkhart HM, Connolly HM, Dearani JA, Cetta F, Li Z, Oliver WC, Warnes CA, Schaff HV. Coarctation of the aorta: lifelong surveillance is mandatory following surgical repair. J Am Coll Cardiol. 2013 Sep 10; 62(11):1020-5. View abstract
  15. Brown ML, Park SJ, Sundt TM, Schaff HV. Early thrombosis risk in patients with biologic valves in the aortic position. J Thorac Cardiovasc Surg. 2012 Jul; 144(1):108-11. View abstract
  16. Brown ML, Parker SE, Quiñonez LG, Li Z, Sundt TM. Can the impact of change of surgical teams in cardiovascular surgery be measured by operative mortality or morbidity? A propensity adjusted cohort comparison. Ann Surg. 2011 Feb; 253(2):385-92. View abstract
  17. Le Tourneau T, Pellikka PA, Brown ML, Malouf JF, Mahoney DW, Schaff HV, Enriquez-Sarano M. Clinical outcome of asymptomatic severe aortic stenosis with medical and surgical management: importance of STS score at diagnosis. Ann Thorac Surg. 2010 Dec; 90(6):1876-83. View abstract
  18. Brown ML, Schaff HV, Suri RM, Li Z, Sundt TM, Dearani JA, Enriquez-Sarano M. Regression in left ventricular mass after aortic valve replacement for chronic aortic regurgitation is unrelated to prosthetic valve size. J Thorac Cardiovasc Surg. 2011 Aug; 142(2):e5-9. View abstract
  19. Schaff HV, Brown ML, Lenoch JR. Data entry and data accuracy. J Thorac Cardiovasc Surg. 2010 Nov; 140(5):960-1. View abstract
  20. Brown ML, Schaff HV, Dearani JA, Li Z, Nishimura RA, Ommen SR. Relationship between left ventricular mass, wall thickness, and survival after subaortic septal myectomy for hypertrophic obstructive cardiomyopathy. J Thorac Cardiovasc Surg. 2011 Feb; 141(2):439-43. View abstract
  21. Brown ML, Burkhart HM, Connolly HM, Dearani JA, Hagler DJ, Schaff HV. Late outcomes of reintervention on the descending aorta after repair of aortic coarctation. Circulation. 2010 Sep 14; 122(11 Suppl):S81-4. View abstract
  22. Quiñonez LG, Brown ML, Dearani JA, Burkhart HM, Puga FJ. Axillary arteriovenous fistula for the palliation of complex cyanotic congenital heart disease: is it an effective tool? J Thorac Cardiovasc Surg. 2011 Jan; 141(1):188-92. View abstract
  23. Brown ML, Lenoch JR, Schaff HV. Variability in data: the Society of Thoracic Surgeons National Adult Cardiac Surgery Database. J Thorac Cardiovasc Surg. 2010 Aug; 140(2):267-73. View abstract
  24. Schaff HV, Brown ML, Dearani JA, Abel MD, Ommen SR, Sorajja P, Tajik AJ, Nishimura RA. Apical myectomy: a new surgical technique for management of severely symptomatic patients with apical hypertrophic cardiomyopathy. J Thorac Cardiovasc Surg. 2010 Mar; 139(3):634-40. View abstract
  25. Brown ML, Quiñonez LG, Schaff HV. A pilot study of electronic cardiovascular operative notes: qualitative assessment and challenges in implementation. J Am Coll Surg. 2010 Feb; 210(2):178-84. View abstract
  26. Brown ML, Dearani JA. Ebstein malformation of the tricuspid valve: current concepts in management and outcomes. Curr Treat Options Cardiovasc Med. 2009 Oct; 11(5):396-402. View abstract
  27. Brown ML, Dearani JA, Burkhart HM. The adult with congenital heart disease: medical and surgical considerations for management. Curr Opin Pediatr. 2009 Oct; 21(5):561-4. View abstract
  28. Brown ML, Cedeño AR, Edell ES, Hagler DJ, Schaff HV. Operative strategies for pulmonary artery occlusion secondary to mediastinal fibrosis. Ann Thorac Surg. 2009 Jul; 88(1):233-7. View abstract
  29. Brown ML, Schaff HV, Li Z, Suri RM, Daly RC, Orszulak TA. Results of mitral valve annuloplasty with a standard-sized posterior band: is measuring important? J Thorac Cardiovasc Surg. 2009 Oct; 138(4):886-91. View abstract
  30. Brown ML, Schaff HV, Suri RM, Li Z, Zhuo L, Sundt TM, Dearani JA, Daly RC, Orszulak TA. Indexed left ventricular dimensions best predict survival after aortic valve replacement in patients with aortic valve regurgitation. Ann Thorac Surg. 2009 Apr; 87(4):1170-5; discussion 1175-6. View abstract
  31. Brown ML, Dearani JA, Danielson GK, Cetta F, Connolly HM, Warnes CA, Li Z, Hodge DO, Driscoll DJ. Comparison of the outcome of porcine bioprosthetic versus mechanical prosthetic replacement of the tricuspid valve in the Ebstein anomaly. Am J Cardiol. 2009 Feb 15; 103(4):555-61. View abstract
  32. Brown ML, Quinonez LG, Schaff HV, Sundt TM. What are patients really telling us? Comparison of survey responses and the medical record in cardiovascular surgical patients. Ann Thorac Surg. 2008 Dec; 86(6):1888-96. View abstract
  33. Brown ML, McKellar SH, Sundt TM, Schaff HV. Ministernotomy versus conventional sternotomy for aortic valve replacement: a systematic review and meta-analysis. J Thorac Cardiovasc Surg. 2009 Mar; 137(3):670-679.e5. View abstract
  34. Brown ML, Dearani JA, Danielson GK, Cetta F, Connolly HM, Warnes CA, Li Z, Hodge DO, Driscoll DJ. Effect of operation for Ebstein anomaly on left ventricular function. Am J Cardiol. 2008 Dec 15; 102(12):1724-7. View abstract
  35. McKellar SH, Brown ML, Frye RL, Schaff HV, Sundt TM. Comparison of coronary revascularization procedures in octogenarians: a systematic review and meta-analysis. Nat Clin Pract Cardiovasc Med. 2008 Nov; 5(11):738-46. View abstract
  36. Brown ML, Schaff HV, Sundt TM. Conduit choice for coronary artery bypass grafting after mediastinal radiation. J Thorac Cardiovasc Surg. 2008 Nov; 136(5):1167-71. View abstract
  37. Brown ML, Zayas GE, Abel MD, Young WF, Schaff HV. Mediastinal paragangliomas: the mayo clinic experience. Ann Thorac Surg. 2008 Sep; 86(3):946-51. View abstract
  38. Brown ML, Gersh BJ, Holmes DR, Bailey KR, Sundt TM. From randomized trials to registry studies: translating data into clinical information. Nat Clin Pract Cardiovasc Med. 2008 Oct; 5(10):613-20. View abstract
  39. Brown ML, Dearani JA, Danielson GK, Cetta F, Connolly HM, Warnes CA, Li Z, Hodge DO, Driscoll DJ. Functional status after operation for Ebstein anomaly: the Mayo Clinic experience. J Am Coll Cardiol. 2008 Aug 05; 52(6):460-6. View abstract
  40. Brown ML, Schaff HV, Sarano ME, Li Z, Sundt TM, Dearani JA, Mullany CJ, Orszulak TA. Is the European System for Cardiac Operative Risk Evaluation model valid for estimating the operative risk of patients considered for percutaneous aortic valve replacement? J Thorac Cardiovasc Surg. 2008 Sep; 136(3):566-71. View abstract
  41. Hong J, Park SJ, Mankad SV, Cetta F, Torres NE, Brown ML. Hypoxemia after an axial flow pump Jarvik-2000 implantation: catheter induced. J Thorac Cardiovasc Surg. 2008 Oct; 136(4):1082-3. View abstract
  42. Brown ML, Schaff HV. Surgical management of obstructive hypertrophic cardiomyopathy: the gold standard. Expert Rev Cardiovasc Ther. 2008 Jun; 6(5):715-22. View abstract
  43. Brown ML, Dearani JA, Danielson GK, Cetta F, Connolly HM, Warnes CA, Li Z, Hodge DO, Driscoll DJ. The outcomes of operations for 539 patients with Ebstein anomaly. J Thorac Cardiovasc Surg. 2008 May; 135(5):1120-36, 1136.e1-7. View abstract
  44. Brown ML, Schaff HV, Lahr BD, Mullany CJ, Sundt TM, Dearani JA, McGregor CG, Orszulak TA. Aortic valve replacement in patients aged 50 to 70 years: improved outcome with mechanical versus biologic prostheses. J Thorac Cardiovasc Surg. 2008 Apr; 135(4):878-84; discussion 884. View abstract
  45. Brown ML, Schaff HV. Surgical management of hypertrophic cardiomyopathy in 2007: what is new? World J Surg. 2008 Mar; 32(3):350-4. View abstract
  46. Brown ML, Pellikka PA, Schaff HV, Scott CG, Mullany CJ, Sundt TM, Dearani JA, Daly RC, Orszulak TA. The benefits of early valve replacement in asymptomatic patients with severe aortic stenosis. J Thorac Cardiovasc Surg. 2008 Feb; 135(2):308-15. View abstract
  47. Chaliki HP, Brown ML, Sundt TM, Tajik AJ. Timing of operation in asymptomatic severe aortic stenosis. Expert Rev Cardiovasc Ther. 2007 Nov; 5(6):1065-71. View abstract
  48. Brown ML, Holmes DR, Tajik AJ, Sarano ME, Schaff HV. Safety of same-day coronary angiography in patients undergoing elective valvular heart surgery. Mayo Clin Proc. 2007 May; 82(5):572-4. View abstract
  49. Brown ML, Reeder G, Unni KK, Mullany C. Intraoperative diagnosis of isolated cardiac sarcoid. Heart Lung Circ. 2007 Aug; 16(4):315-7. View abstract
  50. Brown ML, Abel MD, Click RL, Morford RG, Dearani JA, Sundt TM, Orszulak TA, Schaff HV. Systolic anterior motion after mitral valve repair: is surgical intervention necessary? J Thorac Cardiovasc Surg. 2007 Jan; 133(1):136-43. View abstract
  51. Brown M, Zhu Y, Hemmingsen SM, Xiao W. Structural and functional conservation of error-free DNA postreplication repair in Schizosaccharomyces pombe. DNA Repair (Amst). 2002 Nov 03; 1(11):869-80. View abstract