Research Overview

Dr. Melody Duvall’s research centers on the study of immunologic mechanisms underlying diseases of lung inflammation with a focus on cellular targets and molecular pathways for the resolution of lung inflammation and injury. Her current research is focused on investigating the role of natural killer (NK) cells in the pathophysiology of acute RSV-associated lung inflammation in critically ill infants and children with respiratory failure. In collaboration with Dr. Bruce Levy (levylab.bwh.harvard.edu), Dr. Duvall studies the impact of lipid-derived specialized pro-resolving mediators in enhancing NK cell resolution effector functions. She is also a collaborator on translational research projects in patients with severe asthma focused on immune dysregulation and impaired inflammation resolution in this population. The overarching goal of Dr. Duvall’s research is to generate insight into the pathogenesis of severe RSV bronchiolitis and other diseases of overwhelming lung inflammation to identify novel resolution pathways promising for future therapeutic development.

About the Researcher

Dr. Melody Duvall is board-certified in pediatric critical care medicine and is an attending physician in the Medical-Surgical and Cardiac Intensive Care Units. She received her PhD in Immunology from Oxford University, United Kingdom, in 2006 through the NIH-Oxford Graduate Partnership Program and her MD from Washington University in St. Louis School of Medicine in 2008. She completed her pediatrics residency at Boston Children’s Hospital in 2012 and her pediatric critical care medicine fellowship at Boston Children’s Hospital in 2015. She is currently a Scholar in the Pediatric Critcal Care and Trauma Scientist Devleopment Program (PCCTSDP), a national NICHD-funded K12 career developlement award.

Researcher Services

Researcher Areas

  • Viral lung Disease
  • Lung inflammation
  • Inflammation Resolution

Research Departments

Research Divisions

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Duvall MG, Krishnamoorthy N, Levy BD. Non-type 2 inflammation in severe asthma is propelled by neutrophil cytoplasts and maintained by defective resolution. Allergol Int. 2019 Apr; 68(2):143-149. View abstract
  2. Krishnamoorthy N, Douda DN, Brüggemann TR, Ricklefs I, Duvall MG, Abdulnour RE, Martinod K, Tavares L, Wang X, Cernadas M, Israel E, Mauger DT, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Wenzel S, Dunican E, Fahy JV, Irimia D, Wagner DD, Levy BD. Neutrophil cytoplasts induce TH17 differentiation and skew inflammation toward neutrophilia in severe asthma. Sci Immunol. 2018 08 03; 3(26). View abstract
  3. Ricklefs I, Barkas I, Duvall MG, Cernadas M, Grossman NL, Israel E, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Denlinger LC, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Levy BD. ALX receptor ligands define a biochemical endotype for severe asthma. JCI Insight. 2018 03 22; 3(6). View abstract
  4. Duvall MG, Burns JP. Better Late Than Never? Deferred Consent for Minimal Risk Research in the ICU. Crit Care Med. 2017 09; 45(9):1571-1572. View abstract
  5. Ricklefs I, Barkas I, Duvall MG, Cernadas M, Grossman NL, Israel E, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Denlinger LC, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Levy BD. ALX receptor ligands define a biochemical endotype for severe asthma. JCI Insight. 2017 Jul 20; 2(14). View abstract
  6. Duvall MG, Bruggemann TR, Levy BD. Bronchoprotective mechanisms for specialized pro-resolving mediators in the resolution of lung inflammation. Mol Aspects Med. 2017 Dec; 58:44-56. View abstract
  7. Duvall MG, Barnig C, Cernadas M, Ricklefs I, Krishnamoorthy N, Grossman NL, Bhakta NR, Fahy JV, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Israel E, Levy BD. Natural killer cell-mediated inflammation resolution is disabled in severe asthma. Sci Immunol. 2017 Mar 10; 2(9). View abstract
  8. Patel KR, Aven L, Shao F, Krishnamoorthy N, Duvall MG, Levy BD, Ai X. Mast cell-derived neurotrophin 4 mediates allergen-induced airway hyperinnervation in early life. Mucosal Immunol. 2016 11; 9(6):1466-1476. View abstract
  9. Duvall MG, Levy BD. DHA- and EPA-derived resolvins, protectins, and maresins in airway inflammation. Eur J Pharmacol. 2016 Aug 15; 785:144-155. View abstract
  10. Duvall MG, Pikman Y, Kantor DB, Ariagno K, Summers L, Sectish TC, Mullen MP. Pulmonary hypertension associated with scurvy and vitamin deficiencies in an autistic child. Pediatrics. 2013 Dec; 132(6):e1699-703. View abstract
  11. Duvall MG, Precopio ML, Ambrozak DA, Jaye A, McMichael AJ, Whittle HC, Roederer M, Rowland-Jones SL, Koup RA. Polyfunctional T cell responses are a hallmark of HIV-2 infection. Eur J Immunol. 2008 Feb; 38(2):350-63. View abstract
  12. Seale AC, de Jong BC, Zaidi I, Duvall M, Whittle H, Rowland-Jones S, Jaye A. Effects of cryopreservation on CD4+ CD25+ T cells of HIV-1 infected individuals. J Clin Lab Anal. 2008; 22(3):153-8. View abstract
  13. Duvall MG, Loré K, Blaak H, Ambrozak DA, Adams WC, Santos K, Geldmacher C, Mascola JR, McMichael AJ, Jaye A, Whittle HC, Rowland-Jones SL, Koup RA. Dendritic cells are less susceptible to human immunodeficiency virus type 2 (HIV-2) infection than to HIV-1 infection. J Virol. 2007 Dec; 81(24):13486-98. View abstract
  14. Duvall MG, Jaye A, Dong T, Brenchley JM, Alabi AS, Jeffries DJ, van der Sande M, Togun TO, McConkey SJ, Douek DC, McMichael AJ, Whittle HC, Koup RA, Rowland-Jones SL. Maintenance of HIV-specific CD4+ T cell help distinguishes HIV-2 from HIV-1 infection. J Immunol. 2006 Jun 01; 176(11):6973-81. View abstract
  15. Speirs C, van Nimwegen E, Bolton D, Zavolan M, Duvall M, Angleman S, Siegel R, Perelson AS, Lenardo MJ. Analysis of human immunodeficiency virus cytopathicity by using a new method for quantitating viral dynamics in cell culture. J Virol. 2005 Apr; 79(7):4025-32. View abstract
  16. Lenardo MJ, Angleman SB, Bounkeua V, Dimas J, Duvall MG, Graubard MB, Hornung F, Selkirk MC, Speirs CK, Trageser C, Orenstein JO, Bolton DL. Cytopathic killing of peripheral blood CD4(+) T lymphocytes by human immunodeficiency virus type 1 appears necrotic rather than apoptotic and does not require env. J Virol. 2002 May; 76(10):5082-93. View abstract