About the Researcher

Dr. Hughes is a graduate of Boston College and Loyola University-Stritch School of Medicine. She completed otolaryngology training at the University of Connecticut and her pediatric otolaryngology fellowship at Boston Children’s Hospital.

Dr. Hughes is a member of the American Society of Pediatric Otolaryngology National Surgical Quality Improvement Program and is specifically interested in quality improvement research.  Current and past research endeavors include the creation of an airway grading scale to improve tracheotomy patient care and research examining the appropriateness of tympanostomy tube placement.  She has a specific interest in the management of drooling and is working with the American Academy of Cerebral Palsy and Developmental Medicine on the creation of a sialorrhea care pathway.



  • English

Researcher Services

Researcher Areas

  • Quality Improvement
  • Management of Sialorrhea
  • Tympanostomy Tube Placement


Publications powered by Harvard Catalyst Profiles

  1. Hughes A, Choi S. Does intraglandular injection of botulinum toxin improve pediatric sialorrhea? Laryngoscope. 2018 Jul; 128(7):1513-1514. View abstract
  2. Hughes AL, Roberson D, Bannos C, Trudell EK, Vernacchio L. Appropriateness of Tympanostomy Tubes in the Boston Metropolitan Area: Are the AAO-HNSF Guidelines Being Met? Otolaryngol Head Neck Surg. 2017 12; 157(6):1041-1047. View abstract
  3. Hughes A, Danehy A, Adil E. Case 226: Oval Window Atresia. Radiology. 2016 Feb; 278(2):626-31. View abstract
  4. Hughes A, Danehy A, Adil E. Case 226. Radiology. 2015 Oct; 277(1):294-7. View abstract
  5. Hughes AL, Yang E, Vargas SO. A pediatric soft palate mass. Pleomorphic adenoma. JAMA Otolaryngol Head Neck Surg. 2015 Apr; 141(4):391-2. View abstract
  6. Hughes A, Adil EA. What is the role of endoscopic sinus surgery in adult patients with cystic fibrosis? Laryngoscope. 2015 Sep; 125(9):2018-20. View abstract
  7. Gantwerker EA, Hughes AL, Silvera VM, Vargas SO, Rahbar R. Management of a large antenatally recognized foregut duplication cyst of the tongue causing respiratory distress at birth. JAMA Otolaryngol Head Neck Surg. 2014 Nov; 140(11):1065-9. View abstract
  8. Hughes AL, Hussain N, Pafford R, Parham K. Dexamethasone otoprotection in a multidose cisplatin ototoxicity mouse model. Otolaryngol Head Neck Surg. 2014 Jan; 150(1):115-20. View abstract
  9. Chen ZW, Hughes AL, Ghim SH, Letvin NL, Watkins DI. Two more chimpanzee Patr-A locus alleles related to the HLA-A1/A3/A11 family. Immunogenetics. 1993; 38(3):238-40. View abstract
  10. Chen ZW, Shen L, Miller MD, Ghim SH, Hughes AL, Letvin NL. Cytotoxic T lymphocytes do not appear to select for mutations in an immunodominant epitope of simian immunodeficiency virus gag. J Immunol. 1992 Dec 15; 149(12):4060-6. View abstract
  11. Chen ZW, McAdam SN, Hughes AL, Dogon AL, Letvin NL, Watkins DI. Molecular cloning of orangutan and gibbon MHC class I cDNA. The HLA-A and -B loci diverged over 30 million years ago. J Immunol. 1992 Apr 15; 148(8):2547-54. View abstract
  12. Levinson G, Hughes AL, Letvin NL. Sequence and diversity of rhesus monkey T-cell receptor beta chain genes. Immunogenetics. 1992; 35(2):75-88. View abstract
  13. Zhou LJ, Ord DC, Hughes AL, Tedder TF. Structure and domain organization of the CD19 antigen of human, mouse, and guinea pig B lymphocytes. Conservation of the extensive cytoplasmic domain. J Immunol. 1991 Aug 15; 147(4):1424-32. View abstract
  14. Miller MD, Yamamoto H, Hughes AL, Watkins DI, Letvin NL. Definition of an epitope and MHC class I molecule recognized by gag-specific cytotoxic T lymphocytes in SIVmac-infected rhesus monkeys. J Immunol. 1991 Jul 01; 147(1):320-9. View abstract
  15. Watkins DI, Chen ZW, Garber TL, Hughes AL, Letvin NL. Segmental exchange between MHC class I genes in a higher primate: recombination in the gorilla between the ancestor of a human non-functional gene and an A locus gene. Immunogenetics. 1991; 34(3):185-91. View abstract
  16. Watkins DI, Garber TL, Chen ZW, Toukatly G, Hughes AL, Letvin NL. Unusually limited nucleotide sequence variation of the expressed major histocompatibility complex class I genes of a New World primate species (Saguinus oedipus). Immunogenetics. 1991; 33(2):79-89. View abstract
  17. Watkins DI, Chen ZW, Hughes AL, Lagos A, Lewis AM, Shadduck JA, Letvin NL. Syrian hamsters express diverse MHC class I gene products. J Immunol. 1990 Nov 15; 145(10):3483-90. View abstract
  18. Watkins DI, Chen ZW, Hughes AL, Evans MG, Tedder TF, Letvin NL. Evolution of the MHC class I genes of a New World primate from ancestral homologues of human non-classical genes. Nature. 1990 Jul 05; 346(6279):60-3. View abstract
  19. Watkins DI, Chen ZW, Hughes AL, Hodi FS, Letvin NL. Genetically distinct cell populations in naturally occurring bone marrow-chimeric primates express similar MHC class I gene products. J Immunol. 1990 May 15; 144(10):3726-35. View abstract
  20. Watkins DI, Letvin NL, Hughes AL, Tedder TF. Molecular cloning of cDNA that encode MHC class I molecules from a New World primate (Saguinus oedipus). Natural selection acts at positions that may affect peptide presentation to T cells. J Immunol. 1990 Feb 01; 144(3):1136-43. View abstract