Overview

My research focuses on basic science discoveries that bridge newborn medicine and lung stem cell biology. My work is based in the laboratory of Dr. Carla Kim at the Harvard Stem Cell Institute at Boston Children’s Hospital. My project goals focus on the role of lung stem cells in lung injury and repair. I recently published work showing for the first time using lineage tracing techniques that bronchiolar progenitor cells are capable of contributing to alveolar repair after injury. I am currently investigating the regulation of lung stem cell differentiation in the setting of injury, microenvironmental changes, and the extremes of age. I am also investigating the role of mesenchymal stem cell treatment on bronchioalveolar stem cells (BASCs) after lung injury and repair. For my current research work, I have been honored to receive a NIH K12 Child Research Center Grant, a Pulmonary Fibrosis Foundation IM Rosenzweig Young Investigator Award, an Ikaria Advancing Newborn grant and an AMA Foundation SEED grant.

Background

I was raised in Richmond, Virginia and attended University of North Carolina at Chapel Hill. I received my M.D. from University of Virginia and completed my residency in Pediatrics at the University of North Carolina at Chapel Hill. I then completed my Neonatology Fellowship at the Harvard Neonatal-Perinatal Fellowship Program at Boston Children’s Hospital and was honored to serve as Chief Fellow during my last year of training. I am currently a faculty member of the Department of Newborn Medicine at Boston Children’s and a clinical attending physician in the Neonatal Intensive Care Unit providing care to critically ill infants. I am also the Director of the Newborn Medicine Basic Science and Translational Research Seminar Series and the Co-Director of the Division of Newborn Medicine Summer Student Research Program.

Researcher Services

Researcher Areas

  • Lung Stem Cell Biology

Research Departments

Research Divisions

Researcher Labs

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Leeman KT, Pessina P, Lee JH, Kim CF. Mesenchymal Stem Cells Increase Alveolar Differentiation in Lung Progenitor Organoid Cultures. Sci Rep. 2019 Apr 23; 9(1):6479. View abstract
  2. Leeman KT, Barbas K, Strauss J, Adams S, Sussman-Karten K, Kelly A, Parker MGK, Hansen A. Improving Access to Lactation Consultation and Early Breast Milk Use in an Outborn NICU. Pediatr Qual Saf. 2019 Jan-Feb; 4(1):e130. View abstract
  3. Lantos JE, Leeman K, Weidman EK, Dean KE, Peng T, Pearlman AN. Imaging of Temporal Bone Trauma: A Clinicoradiologic Perspective. Neuroimaging Clin N Am. 2019 Feb; 29(1):129-143. View abstract
  4. Nachman E, Clemensen P, Santos K, Cole AR, Polizzotti BD, Hofmann G, Leeman KT, van den Bosch SJ, Kheir JN. A Device for the Quantification of Oxygen Consumption and Caloric Expenditure in the Neonatal Range. Anesth Analg. 2018 07; 127(1):95-104. View abstract
  5. Rohanizadegan M, Abdo SM, O'Donnell-Luria A, Mihalek I, Chen P, Sanders M, Leeman K, Cho M, Hung C, Bodamer O. Utility of rapid whole-exome sequencing in the diagnosis of Niemann-Pick disease type C presenting with fetal hydrops and acute liver failure. Cold Spring Harb Mol Case Stud. 2017 Nov; 3(6). View abstract
  6. Zhu D, Tan J, Maleken AS, Muljadi R, Chan ST, Lau SN, Elgass K, Leaw B, Mockler J, Chambers D, Leeman KT, Kim CF, Wallace EM, Lim R. Human amnion cells reverse acute and chronic pulmonary damage in experimental neonatal lung injury. Stem Cell Res Ther. 2017 Nov 10; 8(1):257. View abstract
  7. Chazen JL, Leeman K, Singh JR, Schweitzer A. Percutaneous CT-guided facet joint synovial cyst rupture: Success with refractory cases and technical considerations. Clin Imaging. 2018 May - Jun; 49:7-11. View abstract
  8. Minkowitz S, Leeman K, Giambrone AE, Kherani JF, Belfi LM, Bartolotta RJ. Emergency Radiology "Boot Camp": Educating Emergency Medicine Residents Using E-learning Radiology Modules. AEM Educ Train. 2017 Jan; 1(1):43-47. View abstract
  9. Christou H, Dizon ML, Farrow KN, Jadcherla SR, Leeman KT, Maheshwari A, Rubin LP, Stansfield BK, Rowitch DH. Sustaining careers of physician-scientists in neonatology and pediatric critical care medicine: formulating supportive departmental policies. Pediatr Res. 2016 11; 80(5):635-640. View abstract
  10. Casey A, Dirks F, Liang OD, Harrach H, Schuette-Nuetgen K, Leeman K, Kim CF, Gerard C, Subramaniam M. Bone marrow-derived multipotent stromal cells attenuate inflammation in obliterative airway disease in mouse tracheal allografts. Stem Cells Int. 2014; 2014:468927. View abstract
  11. Lakshmanan A, Leeman KT, Brodsky D, Parad R. Evaluation of a web-based portal to improve resident education by neonatology fellows. Med Educ Online. 2014; 19:24403. View abstract
  12. Sinkevicius KW, Kriegel C, Bellaria KJ, Lee J, Lau AN, Leeman KT, Zhou P, Beede AM, Fillmore CM, Caswell D, Barrios J, Wong KK, Sholl LM, Schlaeger TM, Bronson RT, Chirieac LR, Winslow MM, Haigis MC, Kim CF. Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10299-304. View abstract
  13. Leeman KT, Dobson L, Towne M, Dukhovny D, Joshi M, Stoler J, Agrawal PB. NPHP3 mutations are associated with neonatal onset multiorgan polycystic disease in two siblings. J Perinatol. 2014 May; 34(5):410-1. View abstract
  14. Leeman KT, Fillmore CM, Kim CF. Lung stem and progenitor cells in tissue homeostasis and disease. Curr Top Dev Biol. 2014; 107:207-233. View abstract
  15. Lakshmanan A, Leeman KT, Brodsky D, Parad R. Evaluation of a web-based portal to improve resident education by neonatology fellows. Med Educ Online. 2014 Jan; 19(1):24403. View abstract
  16. Ghanta S, Leeman KT, Christou H. An update on pharmacologic approaches to bronchopulmonary dysplasia. Semin Perinatol. 2013 Apr; 37(2):115-23. View abstract
  17. Tropea KA, Leder E, Aslam M, Lau AN, Raiser DM, Lee JH, Balasubramaniam V, Fredenburgh LE, Alex Mitsialis S, Kourembanas S, Kim CF. Bronchioalveolar stem cells increase after mesenchymal stromal cell treatment in a mouse model of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2012 May 01; 302(9):L829-37. View abstract
  18. Tropea K, Christou H. Current pharmacologic approaches for prevention and treatment of bronchopulmonary dysplasia. Int J Pediatr. 2012; 2012:598606. View abstract
  19. Bassett E, Vaisman A, Tropea KA, McCall CM, Masutani C, Hanaoka F, Chaney SG. Frameshifts and deletions during in vitro translesion synthesis past Pt-DNA adducts by DNA polymerases beta and eta. DNA Repair (Amst). 2002 Dec 05; 1(12):1003-16. View abstract