Research Overview

My research work is focused on understanding gastrointestinal dysfunction, both epithelial barrier disruption and gastrointestinal dysmotility, in pediatric critical illness. Using a clinical-translational approach I am examining the role of proteases and gastrointestinal hormones on gastrointestinal dysfunction in critical illness. At the bedside I examine patient and clinical care factors that may contribute to gastrointestinal dysfunction in pediatric critical illness and consider how our understanding of the mechanisms underlying gastrointestinal dysfunction at the cellular-molecular level may play a role in developing novel diagnostic and therapeutic strategies for affected patients.

About the Researcher

Dr. Enid E Martinez obtained her MD from the New York University School of Medicine. She subsequently completed residency in Pediatrics at Boston Children’s Hospital and Boston Medical Center through the Boston Combined Residency Program and her fellowship in Pediatric Critical Care Medicine at Boston Children’s Hospital. She is currently an Associate in Critical Care Medicine in the Division of Critical Care Medicine at Boston Children’s Hospital and is pursuing her research at Boston Children’s Hospital and in collaboration with the Mucosal Immunology and Biology Research Center at the Massachusetts General Hospital.

Researcher Services

Researcher Areas

  • Bedside diagnosis and management of gastric emptying
  • Comprehensive nutritional assessments in complex care patients
  • Enteral nutrition identifying limitations and optimizing delivery
  • Mechanisms for gastrointestinal dysfunction in critical illness

Research Departments

Research Divisions

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Martinez EE, Quinn N, Arouchon K, Anzaldi R, Tarrant S, Ma NS, Griffin J, Darras BT, Graham RJ, Mehta NM. Comprehensive nutritional and metabolic assessment in patients with spinal muscular atrophy: Opportunity for an individualized approach. Neuromuscul Disord. 2018 Jun; 28(6):512-519. View abstract
  2. Martinez EE, Smallwood CD, Quinn NL, Ariagno K, Bechard LJ, Duggan CP, Mehta NM. Body Composition in Children with Chronic Illness: Accuracy of Bedside Assessment Techniques. J Pediatr. 2017 11; 190:56-62. View abstract
  3. Martinez EE, Pereira LM, Gura K, Stenquist N, Ariagno K, Nurko S, Mehta NM. Gastric Emptying in Critically Ill Children. JPEN J Parenter Enteral Nutr. 2017 09; 41(7):1100-1109. View abstract
  4. Smallwood C, Martinez E, Quinn N, Ariagno K, Bechard L, Duggan C, Mehta N. 451: INACCURACY OF EXISTING FAT-FREE MASS EQUATIONS IN PEDIATRICS-AND A NEW MACHINE LEARNING METHOD. Crit Care Med. 2016 Dec; 44(12 Suppl 1):189. View abstract
  5. Martinez EE, Ariagno KA, Stenquist N, Anderson D, Muñoz E, Mehta NM. Energy and Protein Delivery in Overweight and Obese Children in the Pediatric Intensive Care Unit. Nutr Clin Pract. 2017 Jun; 32(3):414-419. View abstract
  6. Martinez EE, Mehta NM. The science and art of pediatric critical care nutrition. Curr Opin Crit Care. 2016 08; 22(4):316-24. View abstract
  7. Martinez EE, Forbes PW, O'Brien SE, de Ferranti SD. Census tract based income level and lipid levels in urban pediatric primary care: a retrospective study. BMC Pediatr. 2016 07 08; 16:86. View abstract
  8. Smallwood CD, Martinez EE, Mehta NM. A Comparison of Carbon Dioxide Elimination Measurements Between a Portable Indirect Calorimeter and Volumetric Capnography Monitor: An In Vitro Simulation. Respir Care. 2016 Mar; 61(3):354-8. View abstract
  9. Martinez EE, Douglas K, Nurko S, Mehta NM. Gastric Dysmotility in Critically Ill Children: Pathophysiology, Diagnosis, and Management. Pediatr Crit Care Med. 2015 Nov; 16(9):828-36. View abstract
  10. Martinez EE, Bechard LJ, Smallwood CD, Duggan CP, Graham RJ, Mehta NM. Impact of Individualized Diet Intervention on Body Composition and Respiratory Variables in Children With Respiratory Insufficiency: A Pilot Intervention Study. Pediatr Crit Care Med. 2015 Jul; 16(6):e157-64. View abstract
  11. Martinez EE, Ariagno K, Arriola A, Lara K, Mehta NM. Challenges to nutrition therapy in the pediatric critically ill obese patient. Nutr Clin Pract. 2015 Jun; 30(3):432-9. View abstract
  12. Martinez EE, Smallwood CD, Bechard LJ, Graham RJ, Mehta NM. Metabolic assessment and individualized nutrition in children dependent on mechanical ventilation at home. J Pediatr. 2015 Feb; 166(2):350-7. View abstract
  13. Martinez EE, Bechard LJ, Mehta NM. Nutrition algorithms and bedside nutrient delivery practices in pediatric intensive care units: an international multicenter cohort study. Nutr Clin Pract. 2014 Jun; 29(3):360-7. View abstract