Research Overview

Dr. Modi is currently comparatively assessing EEG and ERP in mouse models of and patients with autism related genetic disorders. Her work is focused on the standardization of data acquisition and analysis in mice and humans for the identification of common features in EEG data that are consistently altered by disease causing mutations and responsive to mechanism based pharmacological treatments. She is also currently collaborating with pharmaceutical companies on preclinical target engagement and proof of mechanism studies using chronic, in vivo EEG based measures of drug response.

About the Researcher

Meera Modi received her Ph.D. in Neuroscience from Emory University under the supervision of Dr. Larry Young. She then completed a postdoctoral fellowship in Pfizer’s Neuroscience Research Unit during which she worked on autism related drug discovery projects. After her time at Pfizer, she became a fellow with Dr. Mustafa Sahin at the Harvard School of Medicine and Boston Children’s Hospital with the goal of characterizing translational electrophysiological biomarkers in animal models and patients with genetic neurodevelopmental disorders. Currently, she is the Scientific Program Manager for the Translational Neuroscience Center (TNC) and Assistant Director of the Translational Neurophysiology Core at Boston Children’s Hospital and a Research Associate with Harvard Medical School. Central to her work at the TNC is the development of parallel biomarkers for preclinical and clinical research.

Researcher Services

Researcher Areas

  • Drug discovery for neurodevelopmental disorder
  • Biomarker development for neurodevelopmental disorder

Research Departments

Researcher Programs

Researcher Centers

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Purtell H, Dhamne SC, Gurnani S, Bainbridge E, Modi ME, Lammers SHT, Super CE, Hameed MQ, Johnson EL, Sahin M, Rotenberg A. Electrographic spikes are common in wildtype mice. Epilepsy Behav. 2018 Dec; 89:94-98. View abstract
  2. Modi ME, Sahin M. A unified circuit for social behavior. Neurobiol Learn Mem. 2018 Aug 24. View abstract
  3. Modi ME, Sahin M. The Way Forward for Mechanism-Based Therapeutics in Genetically Defined Neurodevelopmental Disorders. Clin Pharmacol Ther. 2018 Oct; 104(4):603-606. View abstract
  4. Modi ME, Brooks JM, Guilmette ER, Beyna M, Graf R, Reim D, Schmeisser MJ, Boeckers TM, O'Donnell P, Buhl DL. Hyperactivity and Hypermotivation Associated With Increased Striatal mGluR1 Signaling in a Shank2 Rat Model of Autism. Front Mol Neurosci. 2018; 11:107. View abstract
  5. Kelly E, Schaeffer SM, Dhamne SC, Lipton JO, Lindemann L, Honer M, Jaeschke G, Super CE, Lammers SH, Modi ME, Silverman JL, Dreier JR, Kwiatkowski DJ, Rotenberg A, Sahin M. mGluR5 Modulation of Behavioral and Epileptic Phenotypes in a Mouse Model of Tuberous Sclerosis Complex. Neuropsychopharmacology. 2018 05; 43(6):1457-1465. View abstract
  6. Dhamne SC, Silverman JL, Super CE, Lammers SHT, Hameed MQ, Modi ME, Copping NA, Pride MC, Smith DG, Rotenberg A, Crawley JN, Sahin M. Replicable in vivo physiological and behavioral phenotypes of the Shank3B null mutant mouse model of autism. Mol Autism. 2017; 8:26. View abstract
  7. Modi ME, Sahin M. Translational use of event-related potentials to assess circuit integrity in ASD. Nat Rev Neurol. 2017 Mar; 13(3):160-170. View abstract
  8. Modi ME, Majchrzak MJ, Fonseca KR, Doran A, Osgood S, Vanase-Frawley M, Feyfant E, McInnes H, Darvari R, Buhl DL, Kablaoui NM. Peripheral Administration of a Long-Acting Peptide Oxytocin Receptor Agonist Inhibits Fear-Induced Freezing. J Pharmacol Exp Ther. 2016 08; 358(2):164-72. View abstract
  9. Bosch OJ, Dabrowska J, Modi ME, Johnson ZV, Keebaugh AC, Barrett CE, Ahern TH, Guo J, Grinevich V, Rainnie DG, Neumann ID, Young LJ. Oxytocin in the nucleus accumbens shell reverses CRFR2-evoked passive stress-coping after partner loss in monogamous male prairie voles. Psychoneuroendocrinology. 2016 Feb; 64:66-78. View abstract
  10. Modi ME, Inoue K, Barrett CE, Kittelberger KA, Smith DG, Landgraf R, Young LJ. Melanocortin Receptor Agonists Facilitate Oxytocin-Dependent Partner Preference Formation in the Prairie Vole. Neuropsychopharmacology. 2015 Jul; 40(8):1856-65. View abstract
  11. Barrett CE, Modi ME, Zhang BC, Walum H, Inoue K, Young LJ. Neonatal melanocortin receptor agonist treatment reduces play fighting and promotes adult attachment in prairie voles in a sex-dependent manner. Neuropharmacology. 2014 Oct; 85:357-66. View abstract
  12. Modi ME, Connor-Stroud F, Landgraf R, Young LJ, Parr LA. Aerosolized oxytocin increases cerebrospinal fluid oxytocin in rhesus macaques. Psychoneuroendocrinology. 2014 Jul; 45:49-57. View abstract
  13. Kas MJ, Modi ME, Saxe MD, Smith DG. Advancing the discovery of medications for autism spectrum disorder using new technologies to reveal social brain circuitry in rodents. Psychopharmacology (Berl). 2014 Mar; 231(6):1147-65. View abstract
  14. Parr LA, Modi M, Siebert E, Young LJ. Intranasal oxytocin selectively attenuates rhesus monkeys' attention to negative facial expressions. Psychoneuroendocrinology. 2013 Sep; 38(9):1748-56. View abstract
  15. Keebaugh AC, Modi ME, Barrett CE, Jin C, Young LJ. Identification of variables contributing to superovulation efficiency for production of transgenic prairie voles (Microtus ochrogaster). Reprod Biol Endocrinol. 2012 Jul 27; 10:54. View abstract
  16. Modi ME, Young LJ. The oxytocin system in drug discovery for autism: animal models and novel therapeutic strategies. Horm Behav. 2012 Mar; 61(3):340-50. View abstract
  17. Modi ME, Young LJ. D-cycloserine facilitates socially reinforced learning in an animal model relevant to autism spectrum disorders. Biol Psychiatry. 2011 Aug 01; 70(3):298-304. View abstract
  18. Ahern TH, Modi ME, Burkett JP, Young LJ. Evaluation of two automated metrics for analyzing partner preference tests. J Neurosci Methods. 2009 Sep 15; 182(2):180-8. View abstract
  19. Ahern TH, Modi ME, Burkett JP, Young LJ. WITHDRAWN: Evaluation of two automated systems for analyzing partner preference tests. J Neurosci Methods. 2009 May 03. View abstract