Research Overview

Dr. Ozonoff joined Boston Children’s Hospital in June 2010 and was appointed Associate Professor of Pediatrics at Harvard Medical School in April 2013.  He is currently Director of the Center for Patient Safety and Quality Research, part of the BCH Program for Patient Safety and Quality. His scientific research has focused on two major areas: (1) innovative statistical methods to support public health surveillance and monitor the population-level patterns of influenza and respiratory disease transmission; and (2) patient safety and quality research programs, including a nationwide initiative to improve oral anticoagulation therapy across the Veterans Administration health care system.  

About Al Ozonoff

Dr. Ozonoff’s methodological research develops innovative statistical methods to support and enhance public health surveillance, focusing on spatial, temporal, and spatio-temporal modeling of respiratory disease and surveillance methods.  He holds advisory roles with state and federal public health agencies including the Massachusetts Cancer Registry, the CDC Congenital Heart Disease Consortium, and the International Society for Disease Surveillance.

Researcher Services

Researcher Areas

  • Surveillance; Patient Safety
  • Healthcare Quality

Research Departments

Research Divisions


Publications powered by Harvard Catalyst Profiles

  1. Saito N, Truong MT, Qureshi MM, Lee RJ, Wang JW, Ozonoff A, Sakai O. Correlation of mucositis during head and neck radiotherapy with computed tomography perfusion imaging of the oropharyngeal mucosa. J Comput Assist Tomogr. 2013 Jul-Aug; 37(4):499-504. View abstract
  2. Jeffery C, Ozonoff A, White LF, Pagano M. Distance-based mapping of disease risk. Int J Biostat. 2013 May 07; 9(2):265-90. View abstract
  3. Efird LM, Miller DR, Ash AS, Berlowitz DR, Ozonoff A, Zhao S, Reisman JI, Jasuja GK, Rose AJ. Identifying the risks of anticoagulation in patients with substance abuse. J Gen Intern Med. 2013 Oct; 28(10):1333-9. View abstract
  4. Gordon RW, Anderson SW, Ozonoff A, Rekhi S, Soto JA. Blunt pancreatic trauma: evaluation with MDCT technology. Emerg Radiol. 2013 Aug; 20(4):259-66. View abstract
  5. Walley AY, Xuan Z, Hackman HH, Quinn E, Doe-Simkins M, Sorensen-Alawad A, Ruiz S, Ozonoff A. Opioid overdose rates and implementation of overdose education and nasal naloxone distribution in Massachusetts: interrupted time series analysis. BMJ. 2013 Jan 30; 346:f174. View abstract
  6. Jasuja GK, Reisman JI, Miller DR, Berlowitz DR, Hylek EM, Ash AS, Ozonoff A, Zhao S, Rose AJ. Identifying major hemorrhage with automated data: results of the Veterans Affairs study to improve anticoagulation (VARIA). Thromb Res. 2013 Jan; 131(1):31-6. View abstract
  7. Watanabe M, Sakai O, Ozonoff A, Kussman S, Jara H. Age-related apparent diffusion coefficient changes in the normal brain. Radiology. 2013 Feb; 266(2):575-82. View abstract
  8. Walley AY, Doe-Simkins M, Quinn E, Pierce C, Xuan Z, Ozonoff A. Opioid overdose prevention with intranasal naloxone among people who take methadone. J Subst Abuse Treat. 2013 Feb; 44(2):241-7. View abstract
  9. Anderson SW, Barry B, Soto JA, Ozonoff A, O'Brien M, Jara H. Quantifying hepatic fibrosis using a biexponential model of diffusion weighted imaging in ex vivo liver specimens. Magn Reson Imaging. 2012 Dec; 30(10):1475-82. View abstract
  10. Onal B, Miao X, Ozonoff A, Bauer SB, Retik AB, Nguyen HT. Protective locus against renal scarring on chromosome 11 in affected sib pairs with familial vesicoureteral reflux identified by single nucleotide polymorphism linkage analysis. J Urol. 2012 Oct; 188(4 Suppl):1467-73. View abstract
  11. Boehmer U, Miao X, Ozonoff A. Health behaviors of cancer survivors of different sexual orientations. Cancer Causes Control. 2012 Sep; 23(9):1489-96. View abstract
  12. Scalera JE, Soto JA, Jara H, Ozonoff A, O'Brien M, Anderson SW. Multiexponential T(2) analyses in a murine model of hepatic fibrosis at 11.7 T MRI. NMR Biomed. 2013 Jan; 26(1):83-90. View abstract
  13. Jackson T, Chung MK, Mercier G, Ozonoff A, Subramaniam RM. FDG PET/CT interobserver agreement in head and neck cancer: FDG and CT measurements of the primary tumor site. Nucl Med Commun. 2012 Mar; 33(3):305-12. View abstract
  14. Boehmer U, Timm A, Ozonoff A, Potter J. Applying the Female Sexual Functioning Index to sexual minority women. J Womens Health (Larchmt). 2012 Apr; 21(4):401-9. View abstract
  15. Smith KW, Proctor SP, Ozonoff AL, McClean MD. Urinary biomarkers of occupational jet fuel exposure among Air Force personnel. J Expo Sci Environ Epidemiol. 2012 Jan-Feb; 22(1):35-45. View abstract
  16. Anderson SW, Jara H, Ozonoff A, O'Brien M, Hamilton JA, Soto JA. Effect of disease progression on liver apparent diffusion coefficient and T2 values in a murine model of hepatic fibrosis at 11.7 Tesla MRI. J Magn Reson Imaging. 2012 Jan; 35(1):140-6. View abstract
  17. Marrast L, Evans M, Ozonoff A, Henault LE, Rose AJ. Using highly variable warfarin dosing to identify patients at risk for adverse events. Thromb J. 2011 Oct 10; 9:14. View abstract
  18. Boehmer U, Ozonoff A, Miao X. An ecological analysis of colorectal cancer incidence and mortality: differences by sexual orientation. BMC Cancer. 2011 Sep 21; 11:400. View abstract
  19. Hirsch AE, Jha RM, Yoo AJ, Saxena A, Ozonoff A, Growney MJ, Hirsch JA. The use of vertebral augmentation and external beam radiation therapy in the multimodal management of malignant vertebral compression fractures. Pain Physician. 2011 Sep-Oct; 14(5):447-58. View abstract
  20. Truong MT, Lee R, Saito N, Qureshi MM, Ozonoff A, Romesser PB, Wang J, Sakai O. Correlating computed tomography perfusion changes in the pharyngeal constrictor muscles during head-and-neck radiotherapy to dysphagia outcome. Int J Radiat Oncol Biol Phys. 2012 Feb 01; 82(2):e119-27. View abstract
  21. Habib S, Guermazi A, Ozonoff A, Hayashi D, Crema MD, Roemer FW. MRI-based volumetric assessment of joint effusion in knee osteoarthritis using proton density-weighted fat-suppressed and T1-weighted contrast-enhanced fat-suppressed sequences. Skeletal Radiol. 2011 Dec; 40(12):1581-5. View abstract
  22. Boehmer U, Miao X, Ozonoff A. Cancer survivorship and sexual orientation. Cancer. 2011 Aug 15; 117(16):3796-804. View abstract
  23. Anderson SW, Soto JA, Milch HN, Ozonoff A, O'Brien M, Hamilton JA, Jara HJ. Effect of disease progression on liver apparent diffusion coefficient values in a murine model of NASH at 11.7 Tesla MRI. J Magn Reson Imaging. 2011 Apr; 33(4):882-8. View abstract
  24. Arsenault DA, Potemkin AK, Robinson EM, Fallon EM, Ozonoff A, de Meijer VE, Puder M. Surgical intervention in the setting of parenteral nutrition-associated cholestasis may exacerbate liver injury. J Pediatr Surg. 2011 Jan; 46(1):122-7. View abstract
  25. Berg WA, Madsen KS, Schilling K, Tartar M, Pisano ED, Larsen LH, Narayanan D, Ozonoff A, Miller JP, Kalinyak JE. Breast cancer: comparative effectiveness of positron emission mammography and MR imaging in presurgical planning for the ipsilateral breast. Radiology. 2011 Jan; 258(1):59-72. View abstract
  26. Smith KW, Proctor SP, Ozonoff A, McClean MD. Inhalation exposure to jet fuel (JP8) among U.S. Air Force personnel. J Occup Environ Hyg. 2010 Oct; 7(10):563-72. View abstract
  27. Jha RM, Hirsch AE, Yoo AJ, Ozonoff A, Growney M, Hirsch JA. Palliation of compression fractures in cancer patients by vertebral augmentation: a retrospective analysis. J Neurointerv Surg. 2010 Sep; 2(3):221-8. View abstract
  28. Boden LI, Ozonoff A. Law, behavior, and research design: a final note. Am J Ind Med. 2010 Aug; 53(8):856. View abstract
  29. Fotinos-Hoyer AK, Guermazi A, Jara H, Eckstein F, Ozonoff A, Khard H, Norbash A, Bohndorf K, Roemer FW. Assessment of synovitis in the osteoarthritic knee: Comparison between manual segmentation, semiautomated segmentation, and semiquantitative assessment using contrast-enhanced fat-suppressed T1-weighted MRI. Magn Reson Med. 2010 Aug; 64(2):604-9. View abstract
  30. Young RL, Weinberg J, Vieira V, Ozonoff A, Webster TF. A power comparison of generalized additive models and the spatial scan statistic in a case-control setting. Int J Health Geogr. 2010 Jul 19; 9:37. View abstract
  31. Lewis EI, Ozonoff A, Nguyen CP, Kim M, Slanetz PJ. Breast cancer close to the nipple: does this increase the risk of nodal metastasis at diagnosis? Can Assoc Radiol J. 2011 Aug; 62(3):209-14. View abstract
  32. Anderson SW, Rhea JT, Milch HN, Ozonoff A, Lucey BC, Soto JA. Influence of body habitus and use of oral contrast on reader confidence in patients with suspected acute appendicitis using 64 MDCT. Emerg Radiol. 2010 Nov; 17(6):445-53. View abstract
  33. Davison JM, Ozonoff A, Imsande HM, Grillone GA, Subramaniam RM. Squamous cell carcinoma of the palatine tonsils: FDG standardized uptake value ratio as a biomarker to differentiate tonsillar carcinoma from physiologic uptake. Radiology. 2010 May; 255(2):578-85. View abstract
  34. Boden LI, Ozonoff A. Researcher judgment and study design: challenges of using administrative data. Am J Ind Med. 2010 Jan; 53(1):37-41. View abstract
  35. Sasaki A, Hoen AG, Ozonoff A, Suzuki H, Tanabe N, Seki N, Saito R, Brownstein JS. Evidence-based tool for triggering school closures during influenza outbreaks, Japan. Emerg Infect Dis. 2009 Nov; 15(11):1841-3. View abstract
  36. Anderson SW, Soto JA, Lucey BC, Ozonoff A, Jordan JD, Ratevosian J, Ulrich AS, Rathlev NK, Mitchell PM, Rebholz C, Feldman JA, Rhea JT. Abdominal 64-MDCT for suspected appendicitis: the use of oral and IV contrast material versus IV contrast material only. AJR Am J Roentgenol. 2009 Nov; 193(5):1282-8. View abstract
  37. Jeffery C, Ozonoff A, White LF, Nuño M, Pagano M. Power to detect spatial disturbances under different levels of geographic aggregation. J Am Med Inform Assoc. 2009 Nov-Dec; 16(6):847-54. View abstract
  38. Hahm HC, Song IH, Ozonoff A, Sassani JC. HIV testing among sexually experienced Asian and Pacific Islander young women association with routine gynecologic care. Womens Health Issues. 2009 Jul-Aug; 19(4):279-88. View abstract
  39. Resnick EA, Bishop M, O'Connell A, Hugo B, Isern G, Timm A, Ozonoff A, Geller AC. The CHEER study to reduce BMI in Elementary School students: a school-based, parent-directed study in Framingham, Massachusetts. J Sch Nurs. 2009 Oct; 25(5):361-72. View abstract
  40. Saito N, Sakai O, Ozonoff A, Jara H. Relaxo-volumetric multispectral quantitative magnetic resonance imaging of the brain over the human lifespan: global and regional aging patterns. Magn Reson Imaging. 2009 Sep; 27(7):895-906. View abstract
  41. Murakami AM, Anderson SW, Soto JA, Kertesz JL, Ozonoff A, Rhea JT. Active extravasation of the abdomen and pelvis in trauma using 64MDCT. Emerg Radiol. 2009 Sep; 16(5):375-82. View abstract
  42. Fan S, Lyon CE, Savage PD, Ozonoff A, Ades PA, Balady GJ. Outcomes and adverse events among patients with implantable cardiac defibrillators in cardiac rehabilitation: a case-controlled study. J Cardiopulm Rehabil Prev. 2009 Jan-Feb; 29(1):40-3. View abstract
  43. Gavett BE, Poon SJ, Ozonoff A, Jefferson AL, Nair AK, Green RC, Stern RA. Diagnostic utility of the NAB List Learning test in Alzheimer's disease and amnestic mild cognitive impairment. J Int Neuropsychol Soc. 2009 Jan; 15(1):121-9. View abstract
  44. Jafri NF, Ayyala RS, Ozonoff A, Jordan-Gray J, Slanetz PJ. Screening mammography: does ethnicity influence patient preferences for higher recall rates given the potential for earlier detection of breast cancer? Radiology. 2008 Dec; 249(3):785-91. View abstract
  45. Jefferson AL, Lambe S, Moser DJ, Byerly LK, Ozonoff A, Karlawish JH. Decisional capacity for research participation in individuals with mild cognitive impairment. J Am Geriatr Soc. 2008 Jul; 56(7):1236-43. View abstract
  46. Adams BJ, Carr JG, Ozonoff A, Lauer MS, Balady GJ. Effect of exercise training in supervised cardiac rehabilitation programs on prognostic variables from the exercise tolerance test. Am J Cardiol. 2008 May 15; 101(10):1403-7. View abstract
  47. Jefferson AL, Byerly LK, Vanderhill S, Lambe S, Wong S, Ozonoff A, Karlawish JH. Characterization of activities of daily living in individuals with mild cognitive impairment. Am J Geriatr Psychiatry. 2008 May; 16(5):375-83. View abstract
  48. Boden LI, Ozonoff A. Capture-recapture estimates of nonfatal workplace injuries and illnesses. Ann Epidemiol. 2008 Jun; 18(6):500-6. View abstract
  49. Mazzini MJ, Stevens GR, Whalen D, Ozonoff A, Balady GJ. Effect of an American Heart Association Get With the Guidelines program-based clinical pathway on referral and enrollment into cardiac rehabilitation after acute myocardial infarction. Am J Cardiol. 2008 Apr 15; 101(8):1084-7. View abstract
  50. Boehmer U, Clark M, Timm A, Ozonoff A. Two means of sampling sexual minority women: how different are the samples of women? J LGBT Health Res. 2008; 4(4):143-51. View abstract
  51. Ozonoff A, Jeffery C, Manjourides J, White LF, Pagano M. Effect of spatial resolution on cluster detection: a simulation study. Int J Health Geogr. 2007 Nov 27; 6:52. View abstract
  52. Hirsch AE, Singh D, Ozonoff A, Slanetz PJ. Educating medical students about radiation oncology: initial results of the oncology education initiative. J Am Coll Radiol. 2007 Oct; 4(10):711-5. View abstract
  53. Rose AJ, Sharman JP, Ozonoff A, Henault LE, Hylek EM. Effectiveness of warfarin among patients with cancer. J Gen Intern Med. 2007 Jul; 22(7):997-1002. View abstract
  54. Vernacchio L, Vezina RM, Ozonoff A, Mitchell AA. Validity of parental reporting of recent episodes of acute otitis media: a Slone Center Office-Based Research (SCOR) Network study. J Am Board Fam Med. 2007 Mar-Apr; 20(2):160-3. View abstract
  55. Jefferson AL, Wong S, Gracer TS, Ozonoff A, Green RC, Stern RA. Geriatric performance on an abbreviated version of the Boston naming test. Appl Neuropsychol. 2007; 14(3):215-23. View abstract
  56. Farraher SW, Jara H, Chang KJ, Ozonoff A, Soto JA. Differentiation of hepatocellular carcinoma and hepatic metastasis from cysts and hemangiomas with calculated T2 relaxation times and the T1/T2 relaxation times ratio. J Magn Reson Imaging. 2006 Dec; 24(6):1333-41. View abstract
  57. Bixby SD, Lucey BC, Soto JA, Theysohn JM, Theyson JM, Ozonoff A, Varghese JC. Perforated versus nonperforated acute appendicitis: accuracy of multidetector CT detection. Radiology. 2006 Dec; 241(3):780-6. View abstract
  58. Saitz R, Palfai TP, Freedner N, Winter MR, Macdonald A, Lu J, Ozonoff A, Rosenbloom DL, Dejong W. Screening and brief intervention online for college students: the ihealth study. Alcohol Alcohol. 2007 Jan-Feb; 42(1):28-36. View abstract
  59. Jefferson AL, Wong S, Bolen E, Ozonoff A, Green RC, Stern RA. Cognitive correlates of HVOT performance differ between individuals with mild cognitive impairment and normal controls. Arch Clin Neuropsychol. 2006 Aug; 21(5):405-12. View abstract
  60. Ozonoff A, Webster T, Vieira V, Weinberg J, Ozonoff D, Aschengrau A. Cluster detection methods applied to the Upper Cape Cod cancer data. Environ Health. 2005 Sep 15; 4:19. View abstract
  61. Ozonoff A, Forsberg L, Bonetti M, Pagano M. Bivariate method for spatio-temporal syndromic surveillance. MMWR Suppl. 2004 Sep 24; 53:59-66. View abstract
  62. Randolph AG, Lange C, Silverman EK, Lazarus R, Silverman ES, Raby B, Brown A, Ozonoff A, Richter B, Weiss ST. The IL12B gene is associated with asthma. Am J Hum Genet. 2004 Oct; 75(4):709-15. View abstract