PUBLICATIONS

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  1. Yang YS, Moynihan KD, Bekdemir A, Dichwalkar TM, Noh MM, Watson N, Melo M, Ingram J, Suh H, Ploegh H, Stellacci FR, Irvine DJ. Targeting small molecule drugs to T cells with antibody-directed cell-penetrating gold nanoparticles. Biomater Sci. 2018 Dec 18; 7(1):113-124. View abstract
  2. Park YG, Sohn CH, Chen R, McCue M, Yun DH, Drummond GT, Ku T, Evans NB, Oak HC, Trieu W, Choi H, Jin X, Lilascharoen V, Wang J, Truttmann MC, Qi HW, Ploegh HL, Golub TR, Chen SC, Frosch MP, Kulik HJ, Lim BK, Chung K. Protection of tissue physicochemical properties using polyfunctional crosslinkers. Nat Biotechnol. 2018 Dec 17. View abstract
  3. Fang T, Lu X, Berger D, Gmeiner C, Cho J, Schalek R, Ploegh H, Lichtman J. Nanobody immunostaining for correlated light and electron microscopy with preservation of ultrastructure. Nat Methods. 2018 Dec; 15(12):1029-1032. View abstract
  4. Kaur M, Kumar D, Butty V, Singh S, Esteban A, Fink GR, Ploegh HL, Sehrawat S. Galectin-3 Regulates ?-Herpesvirus Specific CD8 T Cell Immunity. iScience. 2018 Oct 17; 9:101-119. View abstract
  5. Kwon S, Duarte JN, Li Z, Ling JJ, Cheneval O, Durek T, Schroeder CI, Craik DJ, Ploegh HL. Targeted Delivery of Cyclotides via Conjugation to a Nanobody. ACS Chem Biol. 2018 Oct 19; 13(10):2973-2980. View abstract
  6. Harmand TJ, Bousbaine D, Chan A, Zhang X, Liu DR, Tam JP, Ploegh HL. One-Pot Dual Labeling of IgG 1 and Preparation of C-to-C Fusion Proteins Through a Combination of Sortase A and Butelase 1. Bioconjug Chem. 2018 Oct 17; 29(10):3245-3249. View abstract
  7. Pishesha N, Ingram JR, Ploegh HL. Sortase A: A Model for Transpeptidation and Its Biological Applications. Annu Rev Cell Dev Biol. 2018 10 06; 34:163-188. View abstract
  8. Miles TF, Spiess K, Jude KM, Tsutsumi N, Burg JS, Ingram JR, Waghray D, Hjorto GM, Larsen O, Ploegh HL, Rosenkilde MM, Garcia KC. Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy. Elife. 2018 06 08; 7. View abstract
  9. Woodham AW, Cheloha RW, Ling J, Rashidian M, Kolifrath SC, Mesyngier M, Duarte JN, Bader JM, Skeate JG, Da Silva DM, Kast WM, Ploegh HL. Nanobody-Antigen Conjugates Elicit HPV-Specific Antitumor Immune Responses. Cancer Immunol Res. 2018 07; 6(7):870-880. View abstract
  10. Truttmann MC, Pincus D, Ploegh HL. Chaperone AMPylation modulates aggregation and toxicity of neurodegenerative disease-associated polypeptides. Proc Natl Acad Sci U S A. 2018 05 29; 115(22):E5008-E5017. View abstract
  11. Krall JA, Reinhardt F, Mercury OA, Pattabiraman DR, Brooks MW, Dougan M, Lambert AW, Bierie B, Ploegh HL, Dougan SK, Weinberg RA. The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy. Sci Transl Med. 2018 Apr 11; 10(436). View abstract
  12. Ingram JR, Blomberg OS, Rashidian M, Ali L, Garforth S, Fedorov E, Fedorov AA, Bonanno JB, Le Gall C, Crowley S, Espinosa C, Biary T, Keliher EJ, Weissleder R, Almo SC, Dougan SK, Ploegh HL, Dougan M. Anti-CTLA-4 therapy requires an Fc domain for efficacy. Proc Natl Acad Sci U S A. 2018 04 10; 115(15):3912-3917. View abstract
  13. Tang CH, Chang S, Paton AW, Paton JC, Gabrilovich DI, Ploegh HL, Del Valle JR, Hu CC. Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization. J Cell Biol. 2018 05 07; 217(5):1739-1755. View abstract
  14. Ingram JR, Schmidt FI, Ploegh HL. Exploiting Nanobodies' Singular Traits. Annu Rev Immunol. 2018 Apr 26; 36:695-715. View abstract
  15. Dougan M, Ingram JR, Jeong HJ, Mosaheb MM, Bruck PT, Ali L, Pishesha N, Blomberg O, Tyler PM, Servos MM, Rashidian M, Nguyen QD, von Andrian UH, Ploegh HL, Dougan SK. Targeting Cytokine Therapy to the Pancreatic Tumor Microenvironment Using PD-L1-Specific VHHs. Cancer Immunol Res. 2018 04; 6(4):389-401. View abstract
  16. Pichugin A, Zarling S, Perazzo L, Duffy PE, Ploegh HL, Krzych U. Identification of a Novel CD8 T Cell Epitope Derived from Plasmodium berghei Protective Liver-Stage Antigen. Front Immunol. 2018; 9:91. View abstract
  17. Bachran C, Schröder M, Conrad L, Cragnolini JJ, Tafesse FG, Helming L, Ploegh HL, Swee LK. The activity of myeloid cell-specific VHH immunotoxins is target-, epitope-, subset- and organ dependent. Sci Rep. 2017 Dec 20; 7(1):17916. View abstract
  18. Ploegh H. Machinery that guides immunity. Nature. 2017 11 23; 551(7681):442-443. View abstract
  19. Ren G, Tardi NJ, Matsuda F, Koh KH, Ruiz P, Wei C, Altintas MM, Ploegh H, Reiser J. Podocytes exhibit a specialized protein quality control employing derlin-2 in kidney disease. Am J Physiol Renal Physiol. 2018 Mar 01; 314(3):F471-F482. View abstract
  20. Ingram JR, Dougan M, Rashidian M, Knoll M, Keliher EJ, Garrett S, Garforth S, Blomberg OS, Espinosa C, Bhan A, Almo SC, Weissleder R, Lodish H, Dougan SK, Ploegh HL. PD-L1 is an activation-independent marker of brown adipocytes. Nat Commun. 2017 09 21; 8(1):647. View abstract
  21. Ingram JR, Blomberg OS, Sockolosky JT, Ali L, Schmidt FI, Pishesha N, Espinosa C, Dougan SK, Garcia KC, Ploegh HL, Dougan M. Localized CD47 blockade enhances immunotherapy for murine melanoma. Proc Natl Acad Sci U S A. 2017 09 19; 114(38):10184-10189. View abstract
  22. Antos JM, Ingram J, Fang T, Pishesha N, Truttmann MC, Ploegh HL. Site-Specific Protein Labeling via Sortase-Mediated Transpeptidation. Curr Protoc Protein Sci. 2017 08 01; 89:15.3.1-15.3.19. View abstract
  23. Truttmann MC, Ploegh HL. In vitro AMPylation Assays Using Purified, Recombinant Proteins. Bio Protoc. 2017 Jul 20; 7(14). View abstract
  24. Schmidt FI, Ploegh HL. Editorial: Crystal death: it's not always the inflammasome... J Leukoc Biol. 2017 07; 102(1):1-4. View abstract
  25. Rashidian M, Ingram JR, Dougan M, Dongre A, Whang KA, LeGall C, Cragnolini JJ, Bierie B, Gostissa M, Gorman J, Grotenbreg GM, Bhan A, Weinberg RA, Ploegh HL. Predicting the response to CTLA-4 blockade by longitudinal noninvasive monitoring of CD8 T cells. J Exp Med. 2017 Aug 07; 214(8):2243-2255. View abstract
  26. Clancy-Thompson E, Chen GZ, Tyler PM, Servos MM, Barisa M, Brennan PJ, Ploegh HL, Dougan SK. Monoclonal Invariant NKT (iNKT) Cell Mice Reveal a Role for Both Tissue of Origin and the TCR in Development of iNKT Functional Subsets. J Immunol. 2017 07 01; 199(1):159-171. View abstract
  27. Fang T, Van Elssen CHMJ, Duarte JN, Guzman JS, Chahal JS, Ling J, Ploegh HL. Targeted antigen delivery by an anti-class II MHC VHH elicits focused aMUC1(Tn) immunity. Chem Sci. 2017 Aug 01; 8(8):5591-5597. View abstract
  28. Dongre A, Rashidian M, Reinhardt F, Bagnato A, Keckesova Z, Ploegh HL, Weinberg RA. Epithelial-to-Mesenchymal Transition Contributes to Immunosuppression in Breast Carcinomas. Cancer Res. 2017 08 01; 77(15):3982-3989. View abstract
  29. Truttmann MC, Ploegh HL. rAMPing Up Stress Signaling: Protein AMPylation in Metazoans. Trends Cell Biol. 2017 08; 27(8):608-620. View abstract
  30. Hanke L, Schmidt FI, Knockenhauer KE, Morin B, Whelan SP, Schwartz TU, Ploegh HL. Vesicular stomatitis virus N protein-specific single-domain antibody fragments inhibit replication. EMBO Rep. 2017 06; 18(6):1027-1037. View abstract
  31. Chahal JS, Fang T, Woodham AW, Khan OF, Ling J, Anderson DG, Ploegh HL. An RNA nanoparticle vaccine against Zika virus elicits antibody and CD8+ T cell responses in a mouse model. Sci Rep. 2017 03 21; 7(1):252. View abstract
  32. Pishesha N, Bilate AM, Wibowo MC, Huang NJ, Li Z, Deshycka R, Bousbaine D, Li H, Patterson HC, Dougan SK, Maruyama T, Lodish HF, Ploegh HL. Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease. Proc Natl Acad Sci U S A. 2017 03 21; 114(12):3157-3162. View abstract
  33. Van Elssen CHMJ, Rashidian M, Vrbanac V, Wucherpfennig KW, Habre ZE, Sticht J, Freund C, Jacobsen JT, Cragnolini J, Ingram J, Plaisier L, Spierings E, Tager AM, Ploegh HL. Noninvasive Imaging of Human Immune Responses in a Human Xenograft Model of Graft-Versus-Host Disease. J Nucl Med. 2017 06; 58(6):1003-1008. View abstract
  34. Bardhan NM, Kumar PV, Li Z, Ploegh HL, Grossman JC, Belcher AM, Chen GY. Enhanced Cell Capture on Functionalized Graphene Oxide Nanosheets through Oxygen Clustering. ACS Nano. 2017 02 28; 11(2):1548-1558. View abstract
  35. Wu Q, Ploegh HL, Truttmann MC. Hepta-Mutant Staphylococcus aureus Sortase A (SrtA7m) as a Tool for in Vivo Protein Labeling in Caenorhabditis elegans. ACS Chem Biol. 2017 03 17; 12(3):664-673. View abstract
  36. Sanderson NS, Zimmermann M, Eilinger L, Gubser C, Schaeren-Wiemers N, Lindberg RL, Dougan SK, Ploegh HL, Kappos L, Derfuss T. Cocapture of cognate and bystander antigens can activate autoreactive B cells. Proc Natl Acad Sci U S A. 2017 01 24; 114(4):734-739. View abstract
  37. Truttmann MC, Zheng X, Hanke L, Damon JR, Grootveld M, Krakowiak J, Pincus D, Ploegh HL. Unrestrained AMPylation targets cytosolic chaperones and activates the heat shock response. Proc Natl Acad Sci U S A. 2017 01 10; 114(2):E152-E160. View abstract
  38. Hanke L, Knockenhauer KE, Brewer RC, van Diest E, Schmidt FI, Schwartz TU, Ploegh HL. The Antiviral Mechanism of an Influenza A Virus Nucleoprotein-Specific Single-Domain Antibody Fragment. MBio. 2016 12 13; 7(6). View abstract
  39. Bozzi AT, Bane LB, Weihofen WA, Singharoy A, Guillen ER, Ploegh HL, Schulten K, Gaudet R. Crystal Structure and Conformational Change Mechanism of a Bacterial Nramp-Family Divalent Metal Transporter. Structure. 2016 12 06; 24(12):2102-2114. View abstract
  40. Duarte JN, Cragnolini JJ, Swee LK, Bilate AM, Bader J, Ingram JR, Rashidfarrokhi A, Fang T, Schiepers A, Hanke L, Ploegh HL. Generation of Immunity against Pathogens via Single-Domain Antibody-Antigen Constructs. J Immunol. 2016 12 15; 197(12):4838-4847. View abstract
  41. Swee LK, Tan ZW, Sanecka A, Yoshida N, Patel H, Grotenbreg G, Frickel EM, Ploegh HL. Peripheral self-reactivity regulates antigen-specific CD8 T-cell responses and cell division under physiological conditions. Open Biol. 2016 11; 6(11). View abstract
  42. Chen GY, Li Z, Duarte JN, Esteban A, Cheloha RW, Theile CS, Fink GR, Ploegh HL. Rapid capture and labeling of cells on single domain antibodies-functionalized flow cell. Biosens Bioelectron. 2017 Mar 15; 89(Pt 2):789-794. View abstract
  43. Bilate AM, Bousbaine D, Mesin L, Agudelo M, Leube J, Kratzert A, Dougan SK, Victora GD, Ploegh HL. Tissue-specific emergence of regulatory and intraepithelial T cells from a clonal T cell precursor. Sci Immunol. 2016 Aug 26; 1(2):eaaf7471. View abstract
  44. Hagiwara M, Ling J, Koenig PA, Ploegh HL. Posttranscriptional Regulation of Glycoprotein Quality Control in the Endoplasmic Reticulum Is Controlled by the E2 Ub-Conjugating Enzyme UBC6e. Mol Cell. 2016 09 01; 63(5):753-67. View abstract
  45. Sanecka A, Yoshida N, Dougan SK, Jackson J, Shastri N, Ploegh H, Blanchard N, Frickel EM. Transnuclear CD8 T cells specific for the immunodominant epitope Gra6 lower acute-phase Toxoplasma gondii burden. Immunology. 2016 Nov; 149(3):270-279. View abstract
  46. von Rohrscheidt J, Petrozziello E, Nedjic J, Federle C, Krzyzak L, Ploegh HL, Ishido S, Steinkasserer A, Klein L. Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83. J Exp Med. 2016 08 22; 213(9):1685-94. View abstract
  47. Demircioglu FE, Sosa BA, Ingram J, Ploegh HL, Schwartz TU. Structures of TorsinA and its disease-mutant complexed with an activator reveal the molecular basis for primary dystonia. Elife. 2016 08 04; 5. View abstract
  48. Chahal JS, Khan OF, Cooper CL, McPartlan JS, Tsosie JK, Tilley LD, Sidik SM, Lourido S, Langer R, Bavari S, Ploegh HL, Anderson DG. Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose. Proc Natl Acad Sci U S A. 2016 07 19; 113(29):E4133-42. View abstract
  49. Schmidt FI, Hanke L, Morin B, Brewer R, Brusic V, Whelan SP, Ploegh HL. Phenotypic lentivirus screens to identify functional single domain antibodies. Nat Microbiol. 2016 06 20; 1(8):16080. View abstract
  50. Antos JM, Truttmann MC, Ploegh HL. Recent advances in sortase-catalyzed ligation methodology. Curr Opin Struct Biol. 2016 06; 38:111-8. View abstract
  51. Dura B, Servos MM, Barry RM, Ploegh HL, Dougan SK, Voldman J. Longitudinal multiparameter assay of lymphocyte interactions from onset by microfluidic cell pairing and culture. Proc Natl Acad Sci U S A. 2016 06 28; 113(26):E3599-608. View abstract
  52. Truttmann MC, Cruz VE, Guo X, Engert C, Schwartz TU, Ploegh HL. The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and Histones. PLoS Genet. 2016 05; 12(5):e1006023. View abstract
  53. Sockolosky JT, Dougan M, Ingram JR, Ho CC, Kauke MJ, Almo SC, Ploegh HL, Garcia KC. Durable antitumor responses to CD47 blockade require adaptive immune stimulation. Proc Natl Acad Sci U S A. 2016 May 10; 113(19):E2646-54. View abstract
  54. Schmidt FI, Lu A, Chen JW, Ruan J, Tang C, Wu H, Ploegh HL. A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly. J Exp Med. 2016 05 02; 213(5):771-90. View abstract
  55. Lu A, Li Y, Schmidt FI, Yin Q, Chen S, Fu TM, Tong AB, Ploegh HL, Mao Y, Wu H. Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism. Nat Struct Mol Biol. 2016 05; 23(5):416-25. View abstract
  56. Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS. Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. Nature. 2016 08 18; 536(7616):359. View abstract
  57. Li L, Park E, Ling J, Ingram J, Ploegh H, Rapoport TA. Crystal structure of a substrate-engaged SecY protein-translocation channel. Nature. 2016 Mar 17; 531(7594):395-399. View abstract
  58. Maruyama T, Dougan SK, Truttmann MC, Bilate AM, Ingram JR, Ploegh HL. Corrigendum: Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining. Nat Biotechnol. 2016 Feb; 34(2):210. View abstract
  59. Jahan AS, Lestra M, Swee LK, Fan Y, Lamers MM, Tafesse FG, Theile CS, Spooner E, Bruzzone R, Ploegh HL, Sanyal S. Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling. Proc Natl Acad Sci U S A. 2016 Feb 09; 113(6):E705-14. View abstract
  60. Fang T, Duarte JN, Ling J, Li Z, Guzman JS, Ploegh HL. Structurally Defined aMHC-II Nanobody-Drug Conjugates: A Therapeutic and Imaging System for B-Cell Lymphoma. Angew Chem Int Ed Engl. 2016 Feb 12; 55(7):2416-20. View abstract
  61. Rashidian M, Wang L, Edens JG, Jacobsen JT, Hossain I, Wang Q, Victora GD, Vasdev N, Ploegh H, Liang SH. Enzyme-Mediated Modification of Single-Domain Antibodies for Imaging Modalities with Different Characteristics. Angew Chem Int Ed Engl. 2016 Jan 11; 55(2):528-533. View abstract
  62. Chen GY, Li Z, Theile CS, Bardhan NM, Kumar PV, Duarte JN, Maruyama T, Rashidfarrokh A, Belcher AM, Ploegh HL. Graphene Oxide Nanosheets Modified with Single-Domain Antibodies for Rapid and Efficient Capture of Cells. Chemistry. 2015 Nov 23; 21(48):17178-83. View abstract
  63. Tafesse FG, Rashidfarrokhi A, Schmidt FI, Freinkman E, Dougan S, Dougan M, Esteban A, Maruyama T, Strijbis K, Ploegh HL. Disruption of Sphingolipid Biosynthesis Blocks Phagocytosis of Candida albicans. PLoS Pathog. 2015 Oct; 11(10):e1005188. View abstract
  64. Ingram JR, Knockenhauer KE, Markus BM, Mandelbaum J, Ramek A, Shan Y, Shaw DE, Schwartz TU, Ploegh HL, Lourido S. Allosteric activation of apicomplexan calcium-dependent protein kinases. Proc Natl Acad Sci U S A. 2015 Sep 08; 112(36):E4975-84. View abstract
  65. Irvine D, Ploegh H. Editorial overview: Special section: Immunological engineering. Curr Opin Immunol. 2015 Aug; 35:ix-xi. View abstract
  66. Li Z, Theile CS, Chen GY, Bilate AM, Duarte JN, Avalos AM, Fang T, Barberena R, Sato S, Ploegh HL. Fluorophore-Conjugated Holliday Junctions for Generating Super-Bright Antibodies and Antibody Fragments. Angew Chem Int Ed Engl. 2015 Sep 28; 54(40):11706-10. View abstract
  67. Rashidian M, Keliher E, Dougan M, Juras PK, Cavallari M, Wojtkiewicz GR, Jacobsen J, Edens JG, Tas JM, Victora G, Weissleder R, Ploegh H. The use of 18F-2-fluorodeoxyglucose (FDG) to label antibody fragments for immuno-PET of pancreatic cancer. ACS Cent Sci. 2015 Jun 24; 1(3):142-147. View abstract
  68. Rashidian M, Keliher EJ, Bilate AM, Duarte JN, Wojtkiewicz GR, Jacobsen JT, Cragnolini J, Swee LK, Victora GD, Weissleder R, Ploegh HL. Noninvasive imaging of immune responses. Proc Natl Acad Sci U S A. 2015 May 12; 112(19):6146-51. View abstract
  69. Maruyama T, Dougan SK, Truttmann MC, Bilate AM, Ingram JR, Ploegh HL. Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining. Nat Biotechnol. 2015 May; 33(5):538-42. View abstract
  70. Burg JS, Ingram JR, Venkatakrishnan AJ, Jude KM, Dukkipati A, Feinberg EN, Angelini A, Waghray D, Dror RO, Ploegh HL, Garcia KC. Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor. Science. 2015 Mar 06; 347(6226):1113-7. View abstract
  71. Witte MD, Wu T, Guimaraes CP, Theile CS, Blom AE, Ingram JR, Li Z, Kundrat L, Goldberg SD, Ploegh HL. Site-specific protein modification using immobilized sortase in batch and continuous-flow systems. Nat Protoc. 2015 Mar; 10(3):508-16. View abstract
  72. Jensen KD, Camejo A, Melo MB, Cordeiro C, Julien L, Grotenbreg GM, Frickel EM, Ploegh HL, Young L, Saeij JP. Toxoplasma gondii superinfection and virulence during secondary infection correlate with the exact ROP5/ROP18 allelic combination. MBio. 2015 Feb 24; 6(2):e02280. View abstract
  73. Truttmann MC, Wu Q, Stiegeler S, Duarte JN, Ingram J, Ploegh HL. HypE-specific nanobodies as tools to modulate HypE-mediated target AMPylation. J Biol Chem. 2015 Apr 03; 290(14):9087-100. View abstract
  74. Sun C, Schattgen SA, Pisitkun P, Jorgensen JP, Hilterbrand AT, Wang LJ, West JA, Hansen K, Horan KA, Jakobsen MR, O'Hare P, Adler H, Sun R, Ploegh HL, Damania B, Upton JW, Fitzgerald KA, Paludan SR. Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection. J Immunol. 2015 Feb 15; 194(4):1819-31. View abstract
  75. Dura B, Dougan SK, Barisa M, Hoehl MM, Lo CT, Ploegh HL, Voldman J. Profiling lymphocyte interactions at the single-cell level by microfluidic cell pairing. Nat Commun. 2015 Jan 13; 6:5940. View abstract
  76. Santone M, Aprea S, Wu TY, Cooke MP, Mbow ML, Valiante NM, Rush JS, Dougan S, Avalos A, Ploegh H, De Gregorio E, Buonsanti C, D'Oro U. A new TLR2 agonist promotes cross-presentation by mouse and human antigen presenting cells. Hum Vaccin Immunother. 2015; 11(8):2038-50. View abstract
  77. Ashour J, Schmidt FI, Hanke L, Cragnolini J, Cavallari M, Altenburg A, Brewer R, Ingram J, Shoemaker C, Ploegh HL. Intracellular expression of camelid single-domain antibodies specific for influenza virus nucleoprotein uncovers distinct features of its nuclear localization. J Virol. 2015 Mar; 89(5):2792-800. View abstract
  78. Steiner L, Ploegh H. Herman Eisen (1918-2014). Nature. 2014 Dec 04; 516(7529):38. View abstract
  79. Damon JR, Pincus D, Ploegh HL. tRNA thiolation links translation to stress responses in Saccharomyces cerevisiae. Mol Biol Cell. 2015 Jan 15; 26(2):270-82. View abstract
  80. Wagner K, Kwakkenbos MJ, Claassen YB, Maijoor K, Böhne M, van der Sluijs KF, Witte MD, van Zoelen DJ, Cornelissen LA, Beaumont T, Bakker AQ, Ploegh HL, Spits H. Bispecific antibody generated with sortase and click chemistry has broad antiinfluenza virus activity. Proc Natl Acad Sci U S A. 2014 Nov 25; 111(47):16820-5. View abstract
  81. Swee LK, Lourido S, Bell GW, Ingram JR, Ploegh HL. One-step enzymatic modification of the cell surface redirects cellular cytotoxicity and parasite tropism. ACS Chem Biol. 2015 Feb 20; 10(2):460-5. View abstract
  82. Strijbis K, Yilmaz OH, Dougan SK, Esteban A, Gröne A, Kumamoto CA, Ploegh HL. Intestinal colonization by Candida albicans alters inflammatory responses in Bruton's tyrosine kinase-deficient mice. PLoS One. 2014; 9(11):e112472. View abstract
  83. Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS. CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. Nature. 2015 01 15; 517(7534):386-90. View abstract
  84. Koenig PA, Nicholls PK, Schmidt FI, Hagiwara M, Maruyama T, Frydman GH, Watson N, Page DC, Ploegh HL. The E2 ubiquitin-conjugating enzyme UBE2J1 is required for spermiogenesis in mice. J Biol Chem. 2014 Dec 12; 289(50):34490-502. View abstract
  85. Gilbert LA, Horlbeck MA, Adamson B, Villalta JE, Chen Y, Whitehead EH, Guimaraes C, Panning B, Ploegh HL, Bassik MC, Qi LS, Kampmann M, Weissman JS. Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation. Cell. 2014 Oct 23; 159(3):647-61. View abstract
  86. Wuethrich I, Peeters JG, Blom AE, Theile CS, Li Z, Spooner E, Ploegh HL, Guimaraes CP. Site-specific chemoenzymatic labeling of aerolysin enables the identification of new aerolysin receptors. PLoS One. 2014; 9(10):e109883. View abstract
  87. Lee S, Kang D, Ra EA, Lee TA, Ploegh HL, Park B. Negative self-regulation of TLR9 signaling by its N-terminal proteolytic cleavage product. J Immunol. 2014 Oct 01; 193(7):3726-35. View abstract
  88. Sosa BA, Demircioglu FE, Chen JZ, Ingram J, Ploegh HL, Schwartz TU. How lamina-associated polypeptide 1 (LAP1) activates Torsin. Elife. 2014 Aug 22; 3:e03239. View abstract
  89. Tafesse FG, Strijbis K, Ploegh HL. Quantitative Analysis of Cellular Diacylglycerol Content. Bio Protoc. 2014 Aug 05; 4(15). View abstract
  90. Tafesse FG, Guimaraes CP, Maruyama T, Carette JE, Lory S, Brummelkamp TR, Ploegh HL. GPR107, a G-protein-coupled receptor essential for intoxication by Pseudomonas aeruginosa exotoxin A, localizes to the Golgi and is cleaved by furin. J Biol Chem. 2014 Aug 29; 289(35):24005-18. View abstract
  91. Koenig PA, Ploegh HL. Protein quality control in the endoplasmic reticulum. F1000Prime Rep. 2014; 6:49. View abstract
  92. Shi J, Kundrat L, Pishesha N, Bilate A, Theile C, Maruyama T, Dougan SK, Ploegh HL, Lodish HF. Engineered red blood cells as carriers for systemic delivery of a wide array of functional probes. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10131-6. View abstract
  93. Abdi K, Singh NJ, Spooner E, Kessler BM, Radaev S, Lantz L, Xiao TS, Matzinger P, Sun PD, Ploegh HL. Free IL-12p40 monomer is a polyfunctional adaptor for generating novel IL-12-like heterodimers extracellularly. J Immunol. 2014 Jun 15; 192(12):6028-36. View abstract
  94. Lee CC, Freinkman E, Sabatini DM, Ploegh HL. The protein synthesis inhibitor blasticidin s enters mammalian cells via leucine-rich repeat-containing protein 8D. J Biol Chem. 2014 Jun 13; 289(24):17124-31. View abstract
  95. Feng YX, Sokol ES, Del Vecchio CA, Sanduja S, Claessen JH, Proia TA, Jin DX, Reinhardt F, Ploegh HL, Wang Q, Gupta PB. Epithelial-to-mesenchymal transition activates PERK-eIF2a and sensitizes cells to endoplasmic reticulum stress. Cancer Discov. 2014 Jun; 4(6):702-15. View abstract
  96. Wuethrich I, Guillen E, Ploegh HL. A mouse monoclonal antibody against Alexa Fluor 647. Monoclon Antib Immunodiagn Immunother. 2014 Apr; 33(2):109-20. View abstract
  97. Avalos AM, Ploegh HL. Early BCR Events and Antigen Capture, Processing, and Loading on MHC Class II on B Cells. Front Immunol. 2014; 5:92. View abstract
  98. Claessen JH, Sanyal S, Ploegh HL. The chaperone BAG6 captures dislocated glycoproteins in the cytosol. PLoS One. 2014; 9(3):e90204. View abstract
  99. Avalos AM, Bilate AM, Witte MD, Tai AK, He J, Frushicheva MP, Thill PD, Meyer-Wentrup F, Theile CS, Chakraborty AK, Zhuang X, Ploegh HL. Monovalent engagement of the BCR activates ovalbumin-specific transnuclear B cells. J Exp Med. 2014 Feb 10; 211(2):365-79. View abstract
  100. Zhou P, Shaffer DR, Alvarez Arias DA, Nakazaki Y, Pos W, Torres AJ, Cremasco V, Dougan SK, Cowley GS, Elpek K, Brogdon J, Lamb J, Turley SJ, Ploegh HL, Root DE, Love JC, Dranoff G, Hacohen N, Cantor H, Wucherpfennig KW. In vivo discovery of immunotherapy targets in the tumour microenvironment. Nature. 2014 Feb 06; 506(7486):52-7. View abstract
  101. Strijbis K, Ploegh HL. Secretion of circular proteins using sortase. Methods Mol Biol. 2014; 1174:73-83. View abstract
  102. Ploegh HL. The interest in various immunological subdisciplines waxes and wanes with every new discovery. Preface. Adv Immunol. 2014; 123:ix-x. View abstract
  103. Avalos AM, Meyer-Wentrup F, Ploegh HL. B-cell receptor signaling in lymphoid malignancies and autoimmunity. Adv Immunol. 2014; 123:1-49. View abstract
  104. Sarkar S, Carroll B, Buganim Y, Maetzel D, Ng AH, Cassady JP, Cohen MA, Chakraborty S, Wang H, Spooner E, Ploegh H, Gsponer J, Korolchuk VI, Jaenisch R. Impaired autophagy in the lipid-storage disorder Niemann-Pick type C1 disease. Cell Rep. 2013 Dec 12; 5(5):1302-15. View abstract
  105. Sanyal S, Ashour J, Maruyama T, Altenburg AF, Cragnolini JJ, Bilate A, Avalos AM, Kundrat L, García-Sastre A, Ploegh HL. Type I interferon imposes a TSG101/ISG15 checkpoint at the Golgi for glycoprotein trafficking during influenza virus infection. Cell Host Microbe. 2013 Nov 13; 14(5):510-21. View abstract
  106. Walters BJ, Hallengren JJ, Theile CS, Ploegh HL, Wilson SM, Dobrunz LE. A catalytic independent function of the deubiquitinating enzyme USP14 regulates hippocampal synaptic short-term plasticity and vesicle number. J Physiol. 2014 Feb 15; 592(4):571-86. View abstract
  107. Reiling JH, Olive AJ, Sanyal S, Carette JE, Brummelkamp TR, Ploegh HL, Starnbach MN, Sabatini DM. A CREB3-ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens. Nat Cell Biol. 2013 Dec; 15(12):1473-85. View abstract
  108. Nair N, Buti L, Faenzi E, Buricchi F, Nuti S, Sammicheli C, Tavarini S, Popp MW, Ploegh H, Berti F, Pizza M, Castellino F, Finco O, Rappuoli R, Del Giudice G, Galli G, Bardelli M. Optimized fluorescent labeling to identify memory B cells specific for Neisseria meningitidis serogroup B vaccine antigens ex vivo. Immun Inflamm Dis. 2013 Oct; 1(1):3-13. View abstract
  109. Dougan SK, Ashour J, Karssemeijer RA, Popp MW, Avalos AM, Barisa M, Altenburg AF, Ingram JR, Cragnolini JJ, Guo C, Alt FW, Jaenisch R, Ploegh HL. Antigen-specific B-cell receptor sensitizes B cells to infection by influenza virus. Nature. 2013 Nov 21; 503(7476):406-9. View abstract
  110. Witte MD, Theile CS, Wu T, Guimaraes CP, Blom AE, Ploegh HL. Production of unnaturally linked chimeric proteins using a combination of sortase-catalyzed transpeptidation and click chemistry. Nat Protoc. 2013 Sep; 8(9):1808-19. View abstract
  111. Guimaraes CP, Witte MD, Theile CS, Bozkurt G, Kundrat L, Blom AE, Ploegh HL. Site-specific C-terminal and internal loop labeling of proteins using sortase-mediated reactions. Nat Protoc. 2013 Sep; 8(9):1787-99. View abstract
  112. Theile CS, Witte MD, Blom AE, Kundrat L, Ploegh HL, Guimaraes CP. Site-specific N-terminal labeling of proteins using sortase-mediated reactions. Nat Protoc. 2013 Sep; 8(9):1800-7. View abstract
  113. Dougan SK, Dougan M, Kim J, Turner JA, Ogata S, Cho HI, Jaenisch R, Celis E, Ploegh HL. Transnuclear TRP1-specific CD8 T cells with high or low affinity TCRs show equivalent antitumor activity. Cancer Immunol Res. 2013 Aug; 1(2):99-111. View abstract
  114. Fang M, Xie H, Dougan SK, Ploegh H, van Oudenaarden A. Stochastic cytokine expression induces mixed T helper cell States. PLoS Biol. 2013 Jul; 11(7):e1001618. View abstract
  115. Cai X, Xu Y, Cheung AK, Tomlinson RC, Alcázar-Román A, Murphy L, Billich A, Zhang B, Feng Y, Klumpp M, Rondeau JM, Fazal AN, Wilson CJ, Myer V, Joberty G, Bouwmeester T, Labow MA, Finan PM, Porter JA, Ploegh HL, Baird D, De Camilli P, Tallarico JA, Huang Q. PIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signaling. Chem Biol. 2013 Jul 25; 20(7):912-21. View abstract
  116. Lee CC, Carette JE, Brummelkamp TR, Ploegh HL. A reporter screen in a human haploid cell line identifies CYLD as a constitutive inhibitor of NF-?B. PLoS One. 2013; 8(7):e70339. View abstract
  117. Strijbis K, Tafesse FG, Fairn GD, Witte MD, Dougan SK, Watson N, Spooner E, Esteban A, Vyas VK, Fink GR, Grinstein S, Ploegh HL. Bruton's Tyrosine Kinase (BTK) and Vav1 contribute to Dectin1-dependent phagocytosis of Candida albicans in macrophages. PLoS Pathog. 2013; 9(6):e1003446. View abstract
  118. Koenig PA, Spooner E, Kawamoto N, Strominger JL, Ploegh HL. Amino acid copolymers that alleviate experimental autoimmune encephalomyelitis in vivo interact with heparan sulfates and glycoprotein 96 in APCs. J Immunol. 2013 Jul 01; 191(1):208-16. View abstract
  119. Hess GT, Guimaraes CP, Spooner E, Ploegh HL, Belcher AM. Orthogonal labeling of M13 minor capsid proteins with DNA to self-assemble end-to-end multiphage structures. ACS Synth Biol. 2013 Sep 20; 2(9):490-6. View abstract
  120. Kim J, Huh J, Hwang M, Kwon EH, Jung DJ, Brinkmann MM, Jang MH, Ploegh HL, Kim YM. Acidic amino acid residues in the juxtamembrane region of the nucleotide-sensing TLRs are important for UNC93B1 binding and signaling. J Immunol. 2013 May 15; 190(10):5287-95. View abstract
  121. Saha AK, Kappes F, Mundade A, Deutzmann A, Rosmarin DM, Legendre M, Chatain N, Al-Obaidi Z, Adams BS, Ploegh HL, Ferrando-May E, Mor-Vaknin N, Markovitz DM. Intercellular trafficking of the nuclear oncoprotein DEK. Proc Natl Acad Sci U S A. 2013 Apr 23; 110(17):6847-52. View abstract
  122. Ploegh HL. Logic of the immune system. Cancer Immunol Res. 2013 Jul; 1(1):5-10. View abstract
  123. Tafesse FG, Sanyal S, Ashour J, Guimaraes CP, Hermansson M, Somerharju P, Ploegh HL. Intact sphingomyelin biosynthetic pathway is essential for intracellular transport of influenza virus glycoproteins. Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):6406-11. View abstract
  124. Hendricks GL, Weirich KL, Viswanathan K, Li J, Shriver ZH, Ashour J, Ploegh HL, Kurt-Jones EA, Fygenson DK, Finberg RW, Comolli JC, Wang JP. Sialylneolacto-N-tetraose c (LSTc)-bearing liposomal decoys capture influenza A virus. J Biol Chem. 2013 Mar 22; 288(12):8061-73. View abstract
  125. Claessen JHL, Witte MD, Yoder NC, Zhu AY, Spooner E, Ploegh HL. Catch-and-release probes applied to semi-intact cells reveal ubiquitin-specific protease expression in Chlamydia trachomatis infection. Chembiochem. 2013 Feb 11; 14(3):343-52. View abstract
  126. Swee LK, Guimaraes CP, Sehrawat S, Spooner E, Barrasa MI, Ploegh HL. Sortase-mediated modification of aDEC205 affords optimization of antigen presentation and immunization against a set of viral epitopes. Proc Natl Acad Sci U S A. 2013 Jan 22; 110(4):1428-33. View abstract
  127. Mukherjee S, Zhu J, Zikherman J, Parameswaran R, Kadlecek TA, Wang Q, Au-Yeung B, Ploegh H, Kuriyan J, Das J, Weiss A. Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases. Sci Signal. 2013 Jan 01; 6(256):ra1. View abstract
  128. Sehrawat S, Koenig PA, Kirak O, Schlieker C, Fankhauser M, Ploegh HL. A catalytically inactive mutant of the deubiquitylase YOD-1 enhances antigen cross-presentation. Blood. 2013 Feb 14; 121(7):1145-56. View abstract
  129. Avalos AM, Kirak O, Oelkers JM, Pils MC, Kim YM, Ottinger M, Jaenisch R, Ploegh HL, Brinkmann MM. Cell-specific TLR9 trafficking in primary APCs of transgenic TLR9-GFP mice. J Immunol. 2013 Jan 15; 190(2):695-702. View abstract
  130. Ray A, Amato AA, Bradshaw EM, Felice KJ, DiCapua DB, Goldstein JM, Lundberg IE, Nowak RJ, Ploegh HL, Spooner E, Wu Q, Willis SN, O'Connor KC. Autoantibodies produced at the site of tissue damage provide evidence of humoral autoimmunity in inclusion body myositis. PLoS One. 2012; 7(10):e46709. View abstract
  131. Dougan SK, Ogata S, Hu CC, Grotenbreg GM, Guillen E, Jaenisch R, Ploegh HL. IgG1+ ovalbumin-specific B-cell transnuclear mice show class switch recombination in rare allelically included B cells. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13739-44. View abstract
  132. Witte MD, Cragnolini JJ, Dougan SK, Yoder NC, Popp MW, Ploegh HL. Preparation of unnatural N-to-N and C-to-C protein fusions. Proc Natl Acad Sci U S A. 2012 Jul 24; 109(30):11993-8. View abstract
  133. Hess GT, Cragnolini JJ, Popp MW, Allen MA, Dougan SK, Spooner E, Ploegh HL, Belcher AM, Guimaraes CP. M13 bacteriophage display framework that allows sortase-mediated modification of surface-accessible phage proteins. Bioconjug Chem. 2012 Jul 18; 23(7):1478-87. View abstract
  134. Rosmarin DM, Carette JE, Olive AJ, Starnbach MN, Brummelkamp TR, Ploegh HL. Attachment of Chlamydia trachomatis L2 to host cells requires sulfation. Proc Natl Acad Sci U S A. 2012 Jun 19; 109(25):10059-64. View abstract
  135. Lehmann SM, Krüger C, Park B, Derkow K, Rosenberger K, Baumgart J, Trimbuch T, Eom G, Hinz M, Kaul D, Habbel P, Kälin R, Franzoni E, Rybak A, Nguyen D, Veh R, Ninnemann O, Peters O, Nitsch R, Heppner FL, Golenbock D, Schott E, Ploegh HL, Wulczyn FG, Lehnardt S. An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration. Nat Neurosci. 2012 Jun; 15(6):827-35. View abstract
  136. Sinisi A, Popp MW, Antos JM, Pansegrau W, Savino S, Nissum M, Rappuoli R, Ploegh HL, Buti L. Development of an influenza virus protein array using Sortagging technology. Bioconjug Chem. 2012 Jun 20; 23(6):1119-26. View abstract
  137. Sanyal S, Claessen JH, Ploegh HL. A viral deubiquitylating enzyme restores dislocation of substrates from the endoplasmic reticulum (ER) in semi-intact cells. J Biol Chem. 2012 Jul 06; 287(28):23594-603. View abstract
  138. Davies CW, Chaney J, Korbel G, Ringe D, Petsko GA, Ploegh H, Das C. The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK). Bioorg Med Chem Lett. 2012 Jun 15; 22(12):3900-4. View abstract
  139. Sehrawat S, Kirak O, Koenig PA, Isaacson MK, Marques S, Bozkurt G, Simas JP, Jaenisch R, Ploegh HL. CD8(+) T cells from mice transnuclear for a TCR that recognizes a single H-2K(b)-restricted MHV68 epitope derived from gB-ORF8 help control infection. Cell Rep. 2012 May 31; 1(5):461-71. View abstract
  140. Strijbis K, Spooner E, Ploegh HL. Protein ligation in living cells using sortase. Traffic. 2012 Jun; 13(6):780-9. View abstract
  141. Popp MW, Karssemeijer RA, Ploegh HL. Chemoenzymatic site-specific labeling of influenza glycoproteins as a tool to observe virus budding in real time. PLoS Pathog. 2012; 8(3):e1002604. View abstract
  142. van der Veen AG, Ploegh HL. Ubiquitin-like proteins. Annu Rev Biochem. 2012; 81:323-57. View abstract
  143. Lee CC, Avalos AM, Ploegh HL. Accessory molecules for Toll-like receptors and their function. Nat Rev Immunol. 2012 Feb 03; 12(3):168-79. View abstract
  144. Costantino CM, Spooner E, Ploegh HL, Hafler DA. Class II MHC self-antigen presentation in human B and T lymphocytes. PLoS One. 2012; 7(1):e29805. View abstract
  145. Olvera-Gomez I, Hamilton SE, Xiao Z, Guimaraes CP, Ploegh HL, Hogquist KA, Wang L, Jameson SC. Cholera toxin activates nonconventional adjuvant pathways that induce protective CD8 T-cell responses after epicutaneous vaccination. Proc Natl Acad Sci U S A. 2012 Feb 07; 109(6):2072-7. View abstract
  146. Claessen JH, Ploegh HL. BAT3 guides misfolded glycoproteins out of the endoplasmic reticulum. PLoS One. 2011; 6(12):e28542. View abstract
  147. Guimaraes CP, Carette JE, Varadarajan M, Antos J, Popp MW, Spooner E, Brummelkamp TR, Ploegh HL. Identification of host cell factors required for intoxication through use of modified cholera toxin. J Cell Biol. 2011 Nov 28; 195(5):751-64. View abstract
  148. Smith MH, Ploegh HL, Weissman JS. Road to ruin: targeting proteins for degradation in the endoplasmic reticulum. Science. 2011 Nov 25; 334(6059):1086-90. View abstract
  149. Claessen JH, Kundrat L, Ploegh HL. Protein quality control in the ER: balancing the ubiquitin checkbook. Trends Cell Biol. 2012 Jan; 22(1):22-32. View abstract
  150. Virreira Winter S, Niedelman W, Jensen KD, Rosowski EE, Julien L, Spooner E, Caradonna K, Burleigh BA, Saeij JP, Ploegh HL, Frickel EM. Determinants of GBP recruitment to Toxoplasma gondii vacuoles and the parasitic factors that control it. PLoS One. 2011; 6(9):e24434. View abstract
  151. Avalos AM, Ploegh HL. Competition by inhibitory oligonucleotides prevents binding of CpG to C-terminal TLR9. Eur J Immunol. 2011 Oct; 41(10):2820-7. View abstract
  152. Mashayekhi M, Sandau MM, Dunay IR, Frickel EM, Khan A, Goldszmid RS, Sher A, Ploegh HL, Murphy TL, Sibley LD, Murphy KM. CD8a(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites. Immunity. 2011 Aug 26; 35(2):249-59. View abstract
  153. Klemm EJ, Spooner E, Ploegh HL. Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control. J Biol Chem. 2011 Oct 28; 286(43):37602-14. View abstract
  154. Esteban A, Popp MW, Vyas VK, Strijbis K, Ploegh HL, Fink GR. Fungal recognition is mediated by the association of dectin-1 and galectin-3 in macrophages. Proc Natl Acad Sci U S A. 2011 Aug 23; 108(34):14270-5. View abstract
  155. Carette JE, Guimaraes CP, Wuethrich I, Blomen VA, Varadarajan M, Sun C, Bell G, Yuan B, Muellner MK, Nijman SM, Ploegh HL, Brummelkamp TR. Global gene disruption in human cells to assign genes to phenotypes by deep sequencing. Nat Biotechnol. 2011 May 29; 29(6):542-6. View abstract
  156. Buti L, Spooner E, Van der Veen AG, Rappuoli R, Covacci A, Ploegh HL. Helicobacter pylori cytotoxin-associated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host. Proc Natl Acad Sci U S A. 2011 May 31; 108(22):9238-43. View abstract
  157. Ploegh H. End the wasteful tyranny of reviewer experiments. Nature. 2011 Apr 28; 472(7344):391. View abstract
  158. Bolscher JG, Oudhoff MJ, Nazmi K, Antos JM, Guimaraes CP, Spooner E, Haney EF, Garcia Vallejo JJ, Vogel HJ, van't Hof W, Ploegh HL, Veerman EC. Sortase A as a tool for high-yield histatin cyclization. FASEB J. 2011 Aug; 25(8):2650-8. View abstract
  159. Popp MW, Ploegh HL. Making and breaking peptide bonds: protein engineering using sortase. Angew Chem Int Ed Engl. 2011 May 23; 50(22):5024-32. View abstract
  160. McGehee AM, Strijbis K, Guillen E, Eng T, Kirak O, Ploegh HL. Ubiquitin-dependent control of class II MHC localization is dispensable for antigen presentation and antibody production. PLoS One. 2011 Apr 20; 6(4):e18817. View abstract
  161. Park B, Buti L, Lee S, Matsuwaki T, Spooner E, Brinkmann MM, Nishihara M, Ploegh HL. Granulin is a soluble cofactor for toll-like receptor 9 signaling. Immunity. 2011 Apr 22; 34(4):505-13. View abstract
  162. Ernst R, Claessen JH, Mueller B, Sanyal S, Spooner E, van der Veen AG, Kirak O, Schlieker CD, Weihofen WA, Ploegh HL. Enzymatic blockade of the ubiquitin-proteasome pathway. PLoS Biol. 2011 Mar; 8(3):e1000605. View abstract
  163. Popp MW, Dougan SK, Chuang TY, Spooner E, Ploegh HL. Sortase-catalyzed transformations that improve the properties of cytokines. Proc Natl Acad Sci U S A. 2011 Feb 22; 108(8):3169-74. View abstract
  164. Dougan SK, Hu CC, Paquet ME, Greenblatt MB, Kim J, Lilley BN, Watson N, Ploegh HL. Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes. Mol Cell Biol. 2011 Mar; 31(6):1145-59. View abstract
  165. Van der Veen AG, Schorpp K, Schlieker C, Buti L, Damon JR, Spooner E, Ploegh HL, Jentsch S. Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier. Proc Natl Acad Sci U S A. 2011 Feb 01; 108(5):1763-70. View abstract
  166. Daniel C, Ploegh H, von Boehmer H. Antigen-specific induction of regulatory T cells in vivo and in vitro. Methods Mol Biol. 2011; 707:173-85. View abstract
  167. Artavanis-Tsakonas K, Kasperkovitz PV, Papa E, Cardenas ML, Khan NS, Van der Veen AG, Ploegh HL, Vyas JM. The tetraspanin CD82 is specifically recruited to fungal and bacterial phagosomes prior to acidification. Infect Immun. 2011 Mar; 79(3):1098-106. View abstract
  168. Kirak O, Frickel EM, Grotenbreg GM, Suh H, Jaenisch R, Ploegh HL. Transnuclear mice with pre-defined T cell receptor specificities against Toxoplasma gondii obtained via SCNT. J Vis Exp. 2010 Sep 30; (43). View abstract
  169. Park B, Spooner E, Houser BL, Strominger JL, Ploegh HL. The HCMV membrane glycoprotein US10 selectively targets HLA-G for degradation. J Exp Med. 2010 Aug 30; 207(9):2033-41. View abstract
  170. Sun J, Hartvigsen K, Chou MY, Zhang Y, Sukhova GK, Zhang J, Lopez-Ilasaca M, Diehl CJ, Yakov N, Harats D, George J, Witztum JL, Libby P, Ploegh H, Shi GP. Deficiency of antigen-presenting cell invariant chain reduces atherosclerosis in mice. Circulation. 2010 Aug 24; 122(8):808-20. View abstract
  171. Hegde RS, Ploegh HL. Quality and quantity control at the endoplasmic reticulum. Curr Opin Cell Biol. 2010 Aug; 22(4):437-46. View abstract
  172. Claessen JH, Mueller B, Spooner E, Pivorunas VL, Ploegh HL. The transmembrane segment of a tail-anchored protein determines its degradative fate through dislocation from the endoplasmic reticulum. J Biol Chem. 2010 Jul 02; 285(27):20732-9. View abstract
  173. Kirak O, Frickel EM, Grotenbreg GM, Suh H, Jaenisch R, Ploegh HL. Transnuclear mice with predefined T cell receptor specificities against Toxoplasma gondii obtained via SCNT. Science. 2010 Apr 09; 328(5975):243-8. View abstract
  174. Wilson DC, Grotenbreg GM, Liu K, Zhao Y, Frickel EM, Gubbels MJ, Ploegh HL, Yap GS. Differential regulation of effector- and central-memory responses to Toxoplasma gondii Infection by IL-12 revealed by tracking of Tgd057-specific CD8+ T cells. PLoS Pathog. 2010 Mar 19; 6(3):e1000815. View abstract
  175. Greer PL, Hanayama R, Bloodgood BL, Mardinly AR, Lipton DM, Flavell SW, Kim TK, Griffith EC, Waldon Z, Maehr R, Ploegh HL, Chowdhury S, Worley PF, Steen J, Greenberg ME. The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc. Cell. 2010 Mar 05; 140(5):704-16. View abstract
  176. Artavanis-Tsakonas K, Weihofen WA, Antos JM, Coleman BI, Comeaux CA, Duraisingh MT, Gaudet R, Ploegh HL. Characterization and structural studies of the Plasmodium falciparum ubiquitin and Nedd8 hydrolase UCHL3. J Biol Chem. 2010 Feb 26; 285(9):6857-66. View abstract
  177. Pandya RK, Partridge JR, Love KR, Schwartz TU, Ploegh HL. A structural element within the HUWE1 HECT domain modulates self-ubiquitination and substrate ubiquitination activities. J Biol Chem. 2010 Feb 19; 285(8):5664-73. View abstract
  178. Carette JE, Guimaraes CP, Varadarajan M, Park AS, Wuethrich I, Godarova A, Kotecki M, Cochran BH, Spooner E, Ploegh HL, Brummelkamp TR. Haploid genetic screens in human cells identify host factors used by pathogens. Science. 2009 Nov 27; 326(5957):1231-5. View abstract
  179. Ernst R, Mueller B, Ploegh HL, Schlieker C. The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER. Mol Cell. 2009 Oct 09; 36(1):28-38. View abstract
  180. Hu CC, Dougan SK, Winter SV, Paton AW, Paton JC, Ploegh HL. Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes. J Exp Med. 2009 Oct 26; 206(11):2429-40. View abstract
  181. Monach PA, Hueber W, Kessler B, Tomooka BH, BenBarak M, Simmons BP, Wright J, Thornhill TS, Monestier M, Ploegh H, Robinson WH, Mathis D, Benoist C. A broad screen for targets of immune complexes decorating arthritic joints highlights deposition of nucleosomes in rheumatoid arthritis. Proc Natl Acad Sci U S A. 2009 Sep 15; 106(37):15867-72. View abstract
  182. McGehee AM, Dougan SK, Klemm EJ, Shui G, Park B, Kim YM, Watson N, Wenk MR, Ploegh HL, Hu CC. XBP-1-deficient plasmablasts show normal protein folding but altered glycosylation and lipid synthesis. J Immunol. 2009 Sep 15; 183(6):3690-9. View abstract
  183. Antos JM, Chew GL, Guimaraes CP, Yoder NC, Grotenbreg GM, Popp MW, Ploegh HL. Site-specific N- and C-terminal labeling of a single polypeptide using sortases of different specificity. J Am Chem Soc. 2009 Aug 12; 131(31):10800-1. View abstract
  184. Gredmark-Russ S, Isaacson MK, Kattenhorn L, Cheung EJ, Watson N, Ploegh HL. A gammaherpesvirus ubiquitin-specific protease is involved in the establishment of murine gammaherpesvirus 68 infection. J Virol. 2009 Oct; 83(20):10644-52. View abstract
  185. Green NM, Laws A, Kiefer K, Busconi L, Kim YM, Brinkmann MM, Trail EH, Yasuda K, Christensen SR, Shlomchik MJ, Vogel S, Connor JH, Ploegh H, Eilat D, Rifkin IR, van Seventer JM, Marshak-Rothstein A. Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop. J Immunol. 2009 Aug 01; 183(3):1569-76. View abstract
  186. Costantino CM, Ploegh HL, Hafler DA. Cathepsin S regulates class II MHC processing in human CD4+ HLA-DR+ T cells. J Immunol. 2009 Jul 15; 183(2):945-52. View abstract
  187. Isaacson MK, Ploegh HL. Ubiquitination, ubiquitin-like modifiers, and deubiquitination in viral infection. Cell Host Microbe. 2009 Jun 18; 5(6):559-70. View abstract
  188. Hu CC, Dougan SK, McGehee AM, Love JC, Ploegh HL. XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells. EMBO J. 2009 Jun 03; 28(11):1624-36. View abstract
  189. Love KR, Pandya RK, Spooner E, Ploegh HL. Ubiquitin C-terminal electrophiles are activity-based probes for identification and mechanistic study of ubiquitin conjugating machinery. ACS Chem Biol. 2009 Apr 17; 4(4):275-87. View abstract
  190. Antos JM, Popp MW, Ernst R, Chew GL, Spooner E, Ploegh HL. A straight path to circular proteins. J Biol Chem. 2009 Jun 05; 284(23):16028-36. View abstract
  191. Ploegh H, Amigorena S. Editorial overview. Curr Opin Immunol. 2009 Feb; 21(1):68-9. View abstract
  192. Popp MW, Antos JM, Ploegh HL. Site-specific protein labeling via sortase-mediated transpeptidation. Curr Protoc Protein Sci. 2009 Apr; Chapter 15:Unit 15.3. View abstract
  193. Antos JM, Miller GM, Grotenbreg GM, Ploegh HL. Lipid modification of proteins through sortase-catalyzed transpeptidation. J Am Chem Soc. 2008 Dec 03; 130(48):16338-43. View abstract
  194. Frickel EM, Sahoo N, Hopp J, Gubbels MJ, Craver MP, Knoll LJ, Ploegh HL, Grotenbreg GM. Parasite stage-specific recognition of endogenous Toxoplasma gondii-derived CD8+ T cell epitopes. J Infect Dis. 2008 Dec 01; 198(11):1625-33. View abstract
  195. Popp MW, Artavanis-Tsakonas K, Ploegh HL. Substrate filtering by the active site crossover loop in UCHL3 revealed by sortagging and gain-of-function mutations. J Biol Chem. 2009 Feb 06; 284(6):3593-602. View abstract
  196. Schlieker CD, Van der Veen AG, Damon JR, Spooner E, Ploegh HL. A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway. Proc Natl Acad Sci U S A. 2008 Nov 25; 105(47):18255-60. View abstract
  197. Story CM, Papa E, Hu CC, Ronan JL, Herlihy K, Ploegh HL, Love JC. Profiling antibody responses by multiparametric analysis of primary B cells. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17902-7. View abstract
  198. Park B, Brinkmann MM, Spooner E, Lee CC, Kim YM, Ploegh HL. Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9. Nat Immunol. 2008 Dec; 9(12):1407-14. View abstract
  199. Gredmark-Russ S, Cheung EJ, Isaacson MK, Ploegh HL, Grotenbreg GM. The CD8 T-cell response against murine gammaherpesvirus 68 is directed toward a broad repertoire of epitopes from both early and late antigens. J Virol. 2008 Dec; 82(24):12205-12. View abstract
  200. Bradshaw EM, Kent SC, Tripuraneni V, Orban T, Ploegh HL, Hafler DA, Love JC. Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies. Clin Immunol. 2008 Oct; 129(1):10-8. View abstract
  201. Mueller B, Klemm EJ, Spooner E, Claessen JH, Ploegh HL. SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins. Proc Natl Acad Sci U S A. 2008 Aug 26; 105(34):12325-30. View abstract
  202. Gounaris E, Tung CH, Restaino C, Maehr R, Kohler R, Joyce JA, Ploegh HL, Plough HL, Barrett TA, Weissleder R, Khazaie K. Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth. PLoS One. 2008 Aug 13; 3(8):e2916. View abstract
  203. Vyas JM, Van der Veen AG, Ploegh HL. The known unknowns of antigen processing and presentation. Nat Rev Immunol. 2008 Aug; 8(8):607-18. View abstract
  204. Costantino CM, Hang HC, Kent SC, Hafler DA, Ploegh HL. Lysosomal cysteine and aspartic proteases are heterogeneously expressed and act redundantly to initiate human invariant chain degradation. J Immunol. 2008 Mar 01; 180(5):2876-85. View abstract
  205. Kim YM, Brinkmann MM, Paquet ME, Ploegh HL. UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes. Nature. 2008 Mar 13; 452(7184):234-8. View abstract
  206. Grotenbreg GM, Roan NR, Guillen E, Meijers R, Wang JH, Bell GW, Starnbach MN, Ploegh HL. Discovery of CD8+ T cell epitopes in Chlamydia trachomatis infection through use of caged class I MHC tetramers. Proc Natl Acad Sci U S A. 2008 Mar 11; 105(10):3831-6. View abstract
  207. Jarosinski K, Kattenhorn L, Kaufer B, Ploegh H, Osterrieder N. A herpesvirus ubiquitin-specific protease is critical for efficient T cell lymphoma formation. Proc Natl Acad Sci U S A. 2007 Dec 11; 104(50):20025-30. View abstract
  208. Ploegh HL. Bridging B cell and T cell recognition of antigen. J Immunol. 2007 Dec 01; 179(11):7193. View abstract
  209. Ploegh H. Hidde Ploegh: immunologist, journeyman. Interview by Nicole LeBrasseur. J Cell Biol. 2007 Nov 05; 179(3):364-5. View abstract
  210. Love KR, Catic A, Schlieker C, Ploegh HL. Mechanisms, biology and inhibitors of deubiquitinating enzymes. Nat Chem Biol. 2007 Nov; 3(11):697-705. View abstract
  211. Kario E, Tirosh B, Ploegh HL, Navon A. N-linked glycosylation does not impair proteasomal degradation but affects class I major histocompatibility complex presentation. J Biol Chem. 2008 Jan 04; 283(1):244-54. View abstract
  212. Derkow K, Loddenkemper C, Mintern J, Kruse N, Klugewitz K, Berg T, Wiedenmann B, Ploegh HL, Schott E. Differential priming of CD8 and CD4 T-cells in animal models of autoimmune hepatitis and cholangitis. Hepatology. 2007 Oct; 46(4):1155-65. View abstract
  213. Ploegh HL. The peptide cargo of class I molecules: not just passive passengers. J Immunol. 2007 Oct 01; 179(7):4299-300. View abstract
  214. Popp MW, Antos JM, Grotenbreg GM, Spooner E, Ploegh HL. Sortagging: a versatile method for protein labeling. Nat Chem Biol. 2007 Nov; 3(11):707-8. View abstract
  215. Ploegh HL. A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum. Nature. 2007 Jul 26; 448(7152):435-8. View abstract
  216. Catic A, Fiebiger E, Korbel GA, Blom D, Galardy PJ, Ploegh HL. Screen for ISG15-crossreactive deubiquitinases. PLoS One. 2007 Jul 25; 2(7):e679. View abstract
  217. Gredmark S, Schlieker C, Quesada V, Spooner E, Ploegh HL. A functional ubiquitin-specific protease embedded in the large tegument protein (ORF64) of murine gammaherpesvirus 68 is active during the course of infection. J Virol. 2007 Oct; 81(19):10300-9. View abstract
  218. Kim YM, Brinkmann MM, Ploegh HL. TLRs bent into shape. Nat Immunol. 2007 Jul; 8(7):675-7. View abstract
  219. Catic A, Sun ZY, Ratner DM, Misaghi S, Spooner E, Samuelson J, Wagner G, Ploegh HL. Sequence and structure evolved separately in a ribosomal ubiquitin variant. EMBO J. 2007 Jul 25; 26(14):3474-83. View abstract
  220. Vyas JM, Kim YM, Artavanis-Tsakonas K, Love JC, Van der Veen AG, Ploegh HL. Tubulation of class II MHC compartments is microtubule dependent and involves multiple endolysosomal membrane proteins in primary dendritic cells. J Immunol. 2007 Jun 01; 178(11):7199-210. View abstract
  221. Grotenbreg GM, Nicholson MJ, Fowler KD, Wilbuer K, Octavio L, Yang M, Chakraborty AK, Ploegh HL, Wucherpfennig KW. Empty class II major histocompatibility complex created by peptide photolysis establishes the role of DM in peptide association. J Biol Chem. 2007 Jul 20; 282(29):21425-36. View abstract
  222. Ryu KY, Maehr R, Gilchrist CA, Long MA, Bouley DM, Mueller B, Ploegh HL, Kopito RR. The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance. EMBO J. 2007 Jun 06; 26(11):2693-706. View abstract
  223. Grotenbreg G, Ploegh H. Chemical biology: dressed-up proteins. Nature. 2007 Apr 26; 446(7139):993-5. View abstract
  224. Brinkmann MM, Spooner E, Hoebe K, Beutler B, Ploegh HL, Kim YM. The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling. J Cell Biol. 2007 Apr 23; 177(2):265-75. View abstract
  225. Catic A, Misaghi S, Korbel GA, Ploegh HL. ElaD, a Deubiquitinating protease expressed by E. coli. PLoS One. 2007 Apr 18; 2(4):e381. View abstract
  226. Schlieker C, Weihofen WA, Frijns E, Kattenhorn LM, Gaudet R, Ploegh HL. Structure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymes. Mol Cell. 2007 Mar 09; 25(5):677-87. View abstract
  227. Gavanescu I, Kessler B, Ploegh H, Benoist C, Mathis D. Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity. Proc Natl Acad Sci U S A. 2007 Mar 13; 104(11):4583-7. View abstract
  228. Hang HC, Geutjes EJ, Grotenbreg G, Pollington AM, Bijlmakers MJ, Ploegh HL. Chemical probes for the rapid detection of Fatty-acylated proteins in Mammalian cells. J Am Chem Soc. 2007 Mar 14; 129(10):2744-5. View abstract
  229. Frickel EM, Quesada V, Muething L, Gubbels MJ, Spooner E, Ploegh H, Artavanis-Tsakonas K. Apicomplexan UCHL3 retains dual specificity for ubiquitin and Nedd8 throughout evolution. Cell Microbiol. 2007 Jun; 9(6):1601-10. View abstract
  230. Kumazaki K, Tirosh B, Maehr R, Boes M, Honjo T, Ploegh HL. AID-/-mus-/- mice are agammaglobulinemic and fail to maintain B220-CD138+ plasma cells. J Immunol. 2007 Feb 15; 178(4):2192-203. View abstract
  231. Hang HC, Loureiro J, Spooner E, van der Velden AW, Kim YM, Pollington AM, Maehr R, Starnbach MN, Ploegh HL. Mechanism-based probe for the analysis of cathepsin cysteine proteases in living cells. ACS Chem Biol. 2006 Dec 20; 1(11):713-23. View abstract
  232. Mintern JD, Klemm EJ, Wagner M, Paquet ME, Napier MD, Kim YM, Koszinowski UH, Ploegh HL. Viral interference with B7-1 costimulation: a new role for murine cytomegalovirus fc receptor-1. J Immunol. 2006 Dec 15; 177(12):8422-31. View abstract
  233. Artavanis-Tsakonas K, Love JC, Ploegh HL, Vyas JM. Recruitment of CD63 to Cryptococcus neoformans phagosomes requires acidification. Proc Natl Acad Sci U S A. 2006 Oct 24; 103(43):15945-50. View abstract
  234. Mueller B, Lilley BN, Ploegh HL. SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER. J Cell Biol. 2006 Oct 23; 175(2):261-70. View abstract
  235. Lilley BN, Gilbert JM, Ploegh HL, Benjamin TL. Murine polyomavirus requires the endoplasmic reticulum protein Derlin-2 to initiate infection. J Virol. 2006 Sep; 80(17):8739-44. View abstract
  236. Artavanis-Tsakonas K, Misaghi S, Comeaux CA, Catic A, Spooner E, Duraisingh MT, Ploegh HL. Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum. Mol Microbiol. 2006 Sep; 61(5):1187-95. View abstract
  237. Koch KS, Son KH, Maehr R, Pellicciotta I, Ploegh HL, Zanetti M, Sell S, Leffert HL. Immune-privileged embryonic Swiss mouse STO and STO cell-derived progenitor cells: major histocompatibility complex and cell differentiation antigen expression patterns resemble those of human embryonic stem cell lines. Immunology. 2006 Sep; 119(1):98-115. View abstract
  238. Shringarpure R, Catley L, Bhole D, Burger R, Podar K, Tai YT, Kessler B, Galardy P, Ploegh H, Tassone P, Hideshima T, Mitsiades C, Munshi NC, Chauhan D, Anderson KC. Gene expression analysis of B-lymphoma cells resistant and sensitive to bortezomib. Br J Haematol. 2006 Jul; 134(2):145-56. View abstract
  239. Patterson HC, Kraus M, Kim YM, Ploegh H, Rajewsky K. The B cell receptor promotes B cell activation and proliferation through a non-ITAM tyrosine in the Igalpha cytoplasmic domain. Immunity. 2006 Jul; 25(1):55-65. View abstract
  240. Misaghi S, Balsara ZR, Catic A, Spooner E, Ploegh HL, Starnbach MN. Chlamydia trachomatis-derived deubiquitinating enzymes in mammalian cells during infection. Mol Microbiol. 2006 Jul; 61(1):142-50. View abstract
  241. Vishwanath M, Nishibu A, Saeland S, Ward BR, Mizumoto N, Ploegh HL, Boes M, Takashima A. Development of intravital intermittent confocal imaging system for studying Langerhans cell turnover. J Invest Dermatol. 2006 Nov; 126(11):2452-7. View abstract
  242. Di Bacco A, Ouyang J, Lee HY, Catic A, Ploegh H, Gill G. The SUMO-specific protease SENP5 is required for cell division. Mol Cell Biol. 2006 Jun; 26(12):4489-98. View abstract
  243. Wang J, Loveland AN, Kattenhorn LM, Ploegh HL, Gibson W. High-molecular-weight protein (pUL48) of human cytomegalovirus is a competent deubiquitinating protease: mutant viruses altered in its active-site cysteine or histidine are viable. J Virol. 2006 Jun; 80(12):6003-12. View abstract
  244. Loureiro J, Lilley BN, Spooner E, Noriega V, Tortorella D, Ploegh HL. Signal peptide peptidase is required for dislocation from the endoplasmic reticulum. Nature. 2006 Jun 15; 441(7095):894-7. View abstract
  245. Love JC, Ronan JL, Grotenbreg GM, van der Veen AG, Ploegh HL. A microengraving method for rapid selection of single cells producing antigen-specific antibodies. Nat Biotechnol. 2006 Jun; 24(6):703-7. View abstract
  246. Nishibu A, Ward BR, Jester JV, Ploegh HL, Boes M, Takashima A. Behavioral responses of epidermal Langerhans cells in situ to local pathological stimuli. J Invest Dermatol. 2006 Apr; 126(4):787-96. View abstract
  247. Huang TT, Nijman SM, Mirchandani KD, Galardy PJ, Cohn MA, Haas W, Gygi SP, Ploegh HL, Bernards R, D'Andrea AD. Regulation of monoubiquitinated PCNA by DUB autocleavage. Nat Cell Biol. 2006 Apr; 8(4):339-47. View abstract
  248. Groll M, Berkers CR, Ploegh HL, Ovaa H. Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome. Structure. 2006 Mar; 14(3):451-6. View abstract
  249. Kim YM, Pan JY, Korbel GA, Peperzak V, Boes M, Ploegh HL. Monovalent ligation of the B cell receptor induces receptor activation but fails to promote antigen presentation. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3327-32. View abstract
  250. Loureiro J, Ploegh HL. Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions. Adv Immunol. 2006; 92:225-305. View abstract
  251. Tirosh B, Iwakoshi NN, Glimcher LH, Ploegh HL. Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein response. J Biol Chem. 2006 Mar 03; 281(9):5852-60. View abstract
  252. Schlieker C, Korbel GA, Kattenhorn LM, Ploegh HL. A deubiquitinating activity is conserved in the large tegument protein of the herpesviridae. J Virol. 2005 Dec; 79(24):15582-5. View abstract
  253. Lilley BN, Ploegh HL. Viral modulation of antigen presentation: manipulation of cellular targets in the ER and beyond. Immunol Rev. 2005 Oct; 207:126-44. View abstract
  254. Anderson C, Crimmins S, Wilson JA, Korbel GA, Ploegh HL, Wilson SM. Loss of Usp14 results in reduced levels of ubiquitin in ataxia mice. J Neurochem. 2005 Nov; 95(3):724-31. View abstract
  255. Lilley BN, Ploegh HL. Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane. Proc Natl Acad Sci U S A. 2005 Oct 04; 102(40):14296-301. View abstract
  256. Catic A, Ploegh HL. Ubiquitin--conserved protein or selfish gene? Trends Biochem Sci. 2005 Nov; 30(11):600-4. View abstract
  257. Maehr R, Mintern JD, Herman AE, Lennon-Duménil AM, Mathis D, Benoist C, Ploegh HL. Cathepsin L is essential for onset of autoimmune diabetes in NOD mice. J Clin Invest. 2005 Oct; 115(10):2934-43. View abstract
  258. Altun M, Galardy PJ, Shringarpure R, Hideshima T, LeBlanc R, Anderson KC, Ploegh HL, Kessler BM. Effects of PS-341 on the activity and composition of proteasomes in multiple myeloma cells. Cancer Res. 2005 Sep 01; 65(17):7896-901. View abstract
  259. Boes M, van der Wel N, Peperzak V, Kim YM, Peters PJ, Ploegh H. In vivo control of endosomal architecture by class II-associated invariant chain and cathepsin S. Eur J Immunol. 2005 Sep; 35(9):2552-62. View abstract
  260. Kattenhorn LM, Korbel GA, Kessler BM, Spooner E, Ploegh HL. A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family Herpesviridae. Mol Cell. 2005 Aug 19; 19(4):547-57. View abstract
  261. Tirosh B, Iwakoshi NN, Glimcher LH, Ploegh HL. XBP-1 specifically promotes IgM synthesis and secretion, but is dispensable for degradation of glycoproteins in primary B cells. J Exp Med. 2005 Aug 15; 202(4):505-16. View abstract
  262. Ploegh HL. A molecule's right to choose: how diabetogenic class II MHC products bind peptides. J Clin Invest. 2005 Aug; 115(8):2077-9. View abstract
  263. Tseng HC, Ovaa H, Wei NJ, Ploegh H, Tsai LH. Phosphoproteomic analysis with a solid-phase capture-release-tag approach. Chem Biol. 2005 Jul; 12(7):769-77. View abstract
  264. Guerra L, Teter K, Lilley BN, Stenerlöw B, Holmes RK, Ploegh HL, Sandvig K, Thelestam M, Frisan T. Cellular internalization of cytolethal distending toxin: a new end to a known pathway. Cell Microbiol. 2005 Jul; 7(7):921-34. View abstract
  265. Maehr R, Hang HC, Mintern JD, Kim YM, Cuvillier A, Nishimura M, Yamada K, Shirahama-Noda K, Hara-Nishimura I, Ploegh HL. Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in mice. J Immunol. 2005 Jun 01; 174(11):7066-74. View abstract
  266. Ausubel LJ, O'Connor KC, Baecher-Allen C, Trollmo C, Kessler B, Hekking B, Merritt D, Meyer AL, Kwok B, Ploegh H, Huber BT, Hafler DA. Characterization of in vivo expanded OspA-specific human T-cell clones. Clin Immunol. 2005 Jun; 115(3):313-22. View abstract
  267. Berkers CR, Verdoes M, Lichtman E, Fiebiger E, Kessler BM, Anderson KC, Ploegh HL, Ovaa H, Galardy PJ. Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib. Nat Methods. 2005 May; 2(5):357-62. View abstract
  268. Tirosh B, Iwakoshi NN, Lilley BN, Lee AH, Glimcher LH, Ploegh HL. Human cytomegalovirus protein US11 provokes an unfolded protein response that may facilitate the degradation of class I major histocompatibility complex products. J Virol. 2005 Mar; 79(5):2768-79. View abstract
  269. Borodovsky A, Ovaa H, Meester WJ, Venanzi ES, Bogyo MS, Hekking BG, Ploegh HL, Kessler BM, Overkleeft HS. Small-molecule inhibitors and probes for ubiquitin- and ubiquitin-like-specific proteases. Chembiochem. 2005 Feb; 6(2):287-91. View abstract
  270. Niess JH, Brand S, Gu X, Landsman L, Jung S, McCormick BA, Vyas JM, Boes M, Ploegh HL, Fox JG, Littman DR, Reinecker HC. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science. 2005 Jan 14; 307(5707):254-8. View abstract
  271. Fiebiger E, Tortorella D, Jouvin MH, Kinet JP, Ploegh HL. Cotranslational endoplasmic reticulum assembly of FcepsilonRI controls the formation of functional IgE-binding receptors. J Exp Med. 2005 Jan 17; 201(2):267-77. View abstract
  272. Galardy P, Ploegh HL, Ovaa H. Mechanism-based proteomics tools based on ubiquitin and ubiquitin-like proteins: crystallography, activity profiling, and protease identification. Methods Enzymol. 2005; 399:120-31. View abstract
  273. Ovaa H, Galardy PJ, Ploegh HL. Mechanism-based proteomics tools based on ubiquitin and ubiquitin-like proteins: synthesis of active site-directed probes. Methods Enzymol. 2005; 399:468-78. View abstract
  274. Misaghi S, Pacold ME, Blom D, Ploegh HL, Korbel GA. Using a small molecule inhibitor of peptide: N-glycanase to probe its role in glycoprotein turnover. Chem Biol. 2004 Dec; 11(12):1677-87. View abstract
  275. Misaghi S, Galardy PJ, Meester WJ, Ovaa H, Ploegh HL, Gaudet R. Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate. J Biol Chem. 2005 Jan 14; 280(2):1512-20. View abstract
  276. van der Marel G, Ploegh H. Obituary: Jacques H. van Boom (1937-2004). Nature. 2004 Oct 14; 431(7010):755. View abstract
  277. Kattenhorn LM, Mills R, Wagner M, Lomsadze A, Makeev V, Borodovsky M, Ploegh HL, Kessler BM. Identification of proteins associated with murine cytomegalovirus virions. J Virol. 2004 Oct; 78(20):11187-97. View abstract
  278. Hang HC, Ploegh H. Catching proteases in action with microarrays. Chem Biol. 2004 Oct; 11(10):1328-30. View abstract
  279. Röhn TA, Boes M, Wolters D, Spindeldreher S, Müller B, Langen H, Ploegh H, Vogt AB, Kropshofer H. Upregulation of the CLIP self peptide on mature dendritic cells antagonizes T helper type 1 polarization. Nat Immunol. 2004 Sep; 5(9):909-18. View abstract
  280. Maehr R, Kraus M, Ploegh HL. Mice deficient in invariant-chain and MHC class II exhibit a normal mature B2 cell compartment. Eur J Immunol. 2004 Aug; 34(8):2230-6. View abstract
  281. Catic A, Collins C, Church GM, Ploegh HL. Preferred in vivo ubiquitination sites. Bioinformatics. 2004 Dec 12; 20(18):3302-7. View abstract
  282. Harrison SC, Alberts B, Ehrenfeld E, Enquist L, Fineberg H, McKnight SL, Moss B, O'Donnell M, Ploegh H, Schmid SL, Walter KP, Theriot J. Discovery of antivirals against smallpox. Proc Natl Acad Sci U S A. 2004 Aug 03; 101(31):11178-92. View abstract
  283. Boes M, Ploegh HL. Translating cell biology in vitro to immunity in vivo. Nature. 2004 Jul 08; 430(6996):264-71. View abstract
  284. Lilley BN, Ploegh HL. A membrane protein required for dislocation of misfolded proteins from the ER. Nature. 2004 Jun 24; 429(6994):834-40. View abstract
  285. van Swieten PF, Maehr R, van den Nieuwendijk AM, Kessler BM, Reich M, Wong CS, Kalbacher H, Leeuwenburgh MA, Driessen C, van der Marel GA, Ploegh HL, Overkleeft HS. Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases. Bioorg Med Chem Lett. 2004 Jun 21; 14(12):3131-4. View abstract
  286. Ploegh HL. Immunology. Nothing 'gainst time's scythe can make defense... Science. 2004 May 28; 304(5675):1262-3. View abstract
  287. Boes M, Cuvillier A, Ploegh H. Membrane specializations and endosome maturation in dendritic cells and B cells. Trends Cell Biol. 2004 Apr; 14(4):175-83. View abstract
  288. Schmidt-Supprian M, Tian J, Grant EP, Pasparakis M, Maehr R, Ovaa H, Ploegh HL, Coyle AJ, Rajewsky K. Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation. Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13):4566-71. View abstract
  289. Palliser D, Ploegh H, Boes M. Myeloid differentiation factor 88 is required for cross-priming in vivo. J Immunol. 2004 Mar 15; 172(6):3415-21. View abstract
  290. Evans PC, Ovaa H, Hamon M, Kilshaw PJ, Hamm S, Bauer S, Ploegh HL, Smith TS. Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity. Biochem J. 2004 Mar 15; 378(Pt 3):727-34. View abstract
  291. Cohen HY, Lavu S, Bitterman KJ, Hekking B, Imahiyerobo TA, Miller C, Frye R, Ploegh H, Kessler BM, Sinclair DA. Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. Mol Cell. 2004 Mar 12; 13(5):627-38. View abstract
  292. Hemelaar J, Galardy PJ, Borodovsky A, Kessler BM, Ploegh HL, Ovaa H. Chemistry-based functional proteomics: mechanism-based activity-profiling tools for ubiquitin and ubiquitin-like specific proteases. J Proteome Res. 2004 Mar-Apr; 3(2):268-76. View abstract
  293. Ovaa H, Kessler BM, Rolén U, Galardy PJ, Ploegh HL, Masucci MG. Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells. Proc Natl Acad Sci U S A. 2004 Feb 24; 101(8):2253-8. View abstract
  294. Fiebiger E, Hirsch C, Vyas JM, Gordon E, Ploegh HL, Tortorella D. Dissection of the dislocation pathway for type I membrane proteins with a new small molecule inhibitor, eeyarestatin. Mol Biol Cell. 2004 Apr; 15(4):1635-46. View abstract
  295. Gil-Torregrosa BC, Lennon-Duménil AM, Kessler B, Guermonprez P, Ploegh HL, Fruci D, van Endert P, Amigorena S. Control of cross-presentation during dendritic cell maturation. Eur J Immunol. 2004 Feb; 34(2):398-407. View abstract
  296. Bryant P, Ploegh H. Class II MHC peptide loading by the professionals. Curr Opin Immunol. 2004 Feb; 16(1):96-102. View abstract
  297. Blom D, Hirsch C, Stern P, Tortorella D, Ploegh HL. A glycosylated type I membrane protein becomes cytosolic when peptide: N-glycanase is compromised. EMBO J. 2004 Feb 11; 23(3):650-8. View abstract
  298. Hirsch C, Misaghi S, Blom D, Pacold ME, Ploegh HL. Yeast N-glycanase distinguishes between native and non-native glycoproteins. EMBO Rep. 2004 Feb; 5(2):201-6. View abstract
  299. Misaghi S, Sun ZY, Stern P, Gaudet R, Wagner G, Ploegh H. Structural and functional analysis of human cytomegalovirus US3 protein. J Virol. 2004 Jan; 78(1):413-23. View abstract
  300. Mintern JD, Maurice MM, Ploegh HL, Schott E. Thymic selection and peripheral activation of CD8 T cells by the same class I MHC/peptide complex. J Immunol. 2004 Jan 01; 172(1):699-708. View abstract
  301. Grovender EA, Kellogg B, Singh J, Blom D, Ploegh H, Wittrup KD, Langer RS, Ameer GA. Single-chain antibody fragment-based adsorbent for the extracorporeal removal of beta2-microglobulin. Kidney Int. 2004 Jan; 65(1):310-22. View abstract
  302. Hemelaar J, Borodovsky A, Kessler BM, Reverter D, Cook J, Kolli N, Gan-Erdene T, Wilkinson KD, Gill G, Lima CD, Ploegh HL, Ovaa H. Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins. Mol Cell Biol. 2004 Jan; 24(1):84-95. View abstract
  303. Pieters J, Ploegh H. Microbiology. Chemical warfare and mycobacterial defense. Science. 2003 Dec 12; 302(5652):1900-2. View abstract
  304. Hudson AW, Blom D, Howley PM, Ploegh HL. The ER-lumenal domain of the HHV-7 immunoevasin U21 directs class I MHC molecules to lysosomes. Traffic. 2003 Dec; 4(12):824-37. View abstract
  305. Bertho N, Cerny J, Kim YM, Fiebiger E, Ploegh H, Boes M. Requirements for T cell-polarized tubulation of class II+ compartments in dendritic cells. J Immunol. 2003 Dec 01; 171(11):5689-96. View abstract
  306. Schott E, Bonasio R, Ploegh HL. Elimination in vivo of developing T cells by natural killer cells. J Exp Med. 2003 Oct 20; 198(8):1213-24. View abstract
  307. Boes M, Bertho N, Cerny J, Op den Brouw M, Kirchhausen T, Ploegh H. T cells induce extended class II MHC compartments in dendritic cells in a Toll-like receptor-dependent manner. J Immunol. 2003 Oct 15; 171(8):4081-8. View abstract
  308. Hemelaar J, Lelyveld VS, Kessler BM, Ploegh HL. A single protease, Apg4B, is specific for the autophagy-related ubiquitin-like proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L. J Biol Chem. 2003 Dec 19; 278(51):51841-50. View abstract
  309. Kocks C, Maehr R, Overkleeft HS, Wang EW, Iyer LK, Lennon-Dumenil AM, Ploegh HL, Kessler BM. Functional proteomics of the active cysteine protease content in Drosophila S2 cells. Mol Cell Proteomics. 2003 Nov; 2(11):1188-97. View abstract
  310. Ovaa H, van Swieten PF, Kessler BM, Leeuwenburgh MA, Fiebiger E, van den Nieuwendijk AM, Galardy PJ, van der Marel GA, Ploegh HL, Overkleeft HS. Chemistry in living cells: detection of active proteasomes by a two-step labeling strategy. Angew Chem Int Ed Engl. 2003 Aug 11; 42(31):3626-9. View abstract
  311. Furman MH, Loureiro J, Ploegh HL, Tortorella D. Ubiquitinylation of the cytosolic domain of a type I membrane protein is not required to initiate its dislocation from the endoplasmic reticulum. J Biol Chem. 2003 Sep 12; 278(37):34804-11. View abstract
  312. Kisselev AF, Garcia-Calvo M, Overkleeft HS, Peterson E, Pennington MW, Ploegh HL, Thornberry NA, Goldberg AL. The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites. J Biol Chem. 2003 Sep 19; 278(38):35869-77. View abstract
  313. Lilley BN, Tortorella D, Ploegh HL. Dislocation of a type I membrane protein requires interactions between membrane-spanning segments within the lipid bilayer. Mol Biol Cell. 2003 Sep; 14(9):3690-8. View abstract
  314. Hirsch C, Blom D, Ploegh HL. A role for N-glycanase in the cytosolic turnover of glycoproteins. EMBO J. 2003 Mar 03; 22(5):1036-46. View abstract
  315. Kessler B, Hong X, Petrovic J, Borodovsky A, Dantuma NP, Bogyo M, Overkleeft HS, Ploegh H, Glas R. Pathways accessory to proteasomal proteolysis are less efficient in major histocompatibility complex class I antigen production. J Biol Chem. 2003 Mar 21; 278(12):10013-21. View abstract
  316. Tirosh B, Furman MH, Tortorella D, Ploegh HL. Protein unfolding is not a prerequisite for endoplasmic reticulum-to-cytosol dislocation. J Biol Chem. 2003 Feb 28; 278(9):6664-72. View abstract
  317. Kalka-Moll WM, Tzianabos AO, Bryant PW, Niemeyer M, Ploegh HL, Kasper DL. Zwitterionic polysaccharides stimulate T cells by MHC class II-dependent interactions. J Immunol. 2002 Dec 01; 169(11):6149-53. View abstract
  318. Schott E, Ploegh HL. Mouse MHC class I tetramers that are unable to bind to CD8 reveal the need for CD8 engagement in order to activate naive CD8 T cells. Eur J Immunol. 2002 Dec; 32(12):3425-34. View abstract
  319. Fiebiger E, Maehr R, Villadangos J, Weber E, Erickson A, Bikoff E, Ploegh HL, Lennon-Duménil AM. Invariant chain controls the activity of extracellular cathepsin L. J Exp Med. 2002 Nov 04; 196(9):1263-9. View abstract
  320. Furman MH, Dey N, Tortorella D, Ploegh HL. The human cytomegalovirus US10 gene product delays trafficking of major histocompatibility complex class I molecules. J Virol. 2002 Nov; 76(22):11753-6. View abstract
  321. Vugmeyster Y, Borodovsky A, Maurice MM, Maehr R, Furman MH, Ploegh HL. The ubiquitin-proteasome pathway in thymocyte apoptosis: caspase-dependent processing of the deubiquitinating enzyme USP7 (HAUSP). Mol Immunol. 2002 Nov; 39(7-8):431-41. View abstract
  322. Schott E, Bertho N, Ge Q, Maurice MM, Ploegh HL. Class I negative CD8 T cells reveal the confounding role of peptide-transfer onto CD8 T cells stimulated with soluble H2-Kb molecules. Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21):13735-40. View abstract
  323. Borodovsky A, Ovaa H, Kolli N, Gan-Erdene T, Wilkinson KD, Ploegh HL, Kessler BM. Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family. Chem Biol. 2002 Oct; 9(10):1149-59. View abstract
  324. Furman MH, Ploegh HL. Lessons from viral manipulation of protein disposal pathways. J Clin Invest. 2002 Oct; 110(7):875-9. View abstract
  325. Kessler BM, Glas R, Ploegh HL. MHC class I antigen processing regulated by cytosolic proteolysis-short cuts that alter peptide generation. Mol Immunol. 2002 Oct; 39(3-4):171-9. View abstract
  326. Leggett DS, Hanna J, Borodovsky A, Crosas B, Schmidt M, Baker RT, Walz T, Ploegh H, Finley D. Multiple associated proteins regulate proteasome structure and function. Mol Cell. 2002 Sep; 10(3):495-507. View abstract
  327. Boes M, Cerny J, Massol R, Op den Brouw M, Kirchhausen T, Chen J, Ploegh HL. T-cell engagement of dendritic cells rapidly rearranges MHC class II transport. Nature. 2002 Aug 29; 418(6901):983-8. View abstract
  328. Lennon-Duménil AM, Bakker AH, Maehr R, Fiebiger E, Overkleeft HS, Rosemblatt M, Ploegh HL, Lagaudrière-Gesbert C. Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation. J Exp Med. 2002 Aug 19; 196(4):529-40. View abstract
  329. Tirabassi RS, Ploegh HL. The human cytomegalovirus US8 glycoprotein binds to major histocompatibility complex class I products. J Virol. 2002 Jul; 76(13):6832-5. View abstract
  330. Felbor U, Kessler B, Mothes W, Goebel HH, Ploegh HL, Bronson RT, Olsen BR. Neuronal loss and brain atrophy in mice lacking cathepsins B and L. Proc Natl Acad Sci U S A. 2002 Jun 11; 99(12):7883-8. View abstract
  331. Lorenzo ME, Jung JU, Ploegh HL. Kaposi's sarcoma-associated herpesvirus K3 utilizes the ubiquitin-proteasome system in routing class major histocompatibility complexes to late endocytic compartments. J Virol. 2002 Jun; 76(11):5522-31. View abstract
  332. Rehm A, Engelsberg A, Tortorella D, Körner IJ, Lehmann I, Ploegh HL, Höpken UE. Human cytomegalovirus gene products US2 and US11 differ in their ability to attack major histocompatibility class I heavy chains in dendritic cells. J Virol. 2002 May; 76(10):5043-50. View abstract
  333. Fiebiger E, Story C, Ploegh HL, Tortorella D. Visualization of the ER-to-cytosol dislocation reaction of a type I membrane protein. EMBO J. 2002 Mar 01; 21(5):1041-53. View abstract
  334. Lennon-Duménil AM, Bakker AH, Wolf-Bryant P, Ploegh HL, Lagaudrière-Gesbert C. A closer look at proteolysis and MHC-class-II-restricted antigen presentation. Curr Opin Immunol. 2002 Feb; 14(1):15-21. View abstract
  335. Plüger EB, Boes M, Alfonso C, Schröter CJ, Kalbacher H, Ploegh HL, Driessen C. Specific role for cathepsin S in the generation of antigenic peptides in vivo. Eur J Immunol. 2002 02; 32(2):467-76. View abstract
  336. Ploegh HL. Don Craig Wiley (1944-2001). Nature. 2002 Jan 31; 415(6871):492. View abstract
  337. Lagaudrière-Gesbert C, Newmyer SL, Gregers TF, Bakke O, Ploegh HL. Uncoating ATPase Hsc70 is recruited by invariant chain and controls the size of endocytic compartments. Proc Natl Acad Sci U S A. 2002 Feb 05; 99(3):1515-20. View abstract
  338. Gewurz BE, Ploegh HL, Tortorella D. US2, a human cytomegalovirus-encoded type I membrane protein, contains a non-cleavable amino-terminal signal peptide. J Biol Chem. 2002 Mar 29; 277(13):11306-13. View abstract
  339. Hudson AW, Ploegh HL. The cell biology of antigen presentation. Exp Cell Res. 2002 Jan 01; 272(1):1-7. View abstract
  340. Bryant PW, Lennon-Duménil AM, Fiebiger E, Lagaudrière-Gesbert C, Ploegh HL. Proteolysis and antigen presentation by MHC class II molecules. Adv Immunol. 2002; 80:71-114. View abstract
  341. Furman MH, Ploegh HL, Tortorella D. Membrane-specific, host-derived factors are required for US2- and US11-mediated degradation of major histocompatibility complex class I molecules. J Biol Chem. 2002 Feb 01; 277(5):3258-67. View abstract