Overview

Dr. Sharma’s research focuses on metabolic complications related to antiretroviral medications in children and adolescents with HIV infection.  As children who were perinatally-infected with HIV are getting older and remaining healthier since they have been receiving anti-HIV therapy for many years, we are now beginning to see changes in body composition, an increased risk of diabetes, and increasing risk of other cardiovascular complications in these children.  Dr. Sharma’s research entails evaluating the mechanisms by which these abnormalities occur, and whether life-saving antiretroviral medications may also contribute to some of these complications.  In addition, Dr. Sharma conducts research evaluating infectious complications such as viral infections in pediatric transplant recipients.

Background

Dr. Sharma received her medical degree from the University of Miami Miller School of Medicine. She completed her residency training in pediatrics and fellowship in pediatric infectious diseases and immunology at the University of Miami/Jackson Memorial Medical Center in Miami, Florida.  Dr. Sharma joined the faculty in the Division of Infectious Diseases at Children’s Hospital Boston in 2007.  She currently serves as the Program Director for the pediatric infectious diseases fellowship.

Researcher Services

Researcher Areas

  • Pediatric HIV Prevention Care Treatment
  • Immunocompromised Infectious Diseases

Research Departments

Research Divisions

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Begemann M, Waszak SM, Robinson GW, Jäger N, Sharma T, Knopp C, Kraft F, Moser O, Mynarek M, Guerrini-Rousseau L, Brugieres L, Varlet P, Pietsch T, Bowers DC, Chintagumpala M, Sahm F, Korbel JO, Rutkowski S, Eggermann T, Gajjar A, Northcott P, Elbracht M, Pfister SM, Kontny U, Kurth I. Germline GPR161 Mutations Predispose to Pediatric Medulloblastoma. J Clin Oncol. 2019 Oct 14; JCO1900577. View abstract
  2. Karandikar MV, Milliren CE, Zaboulian R, Peiris P, Sharma T, Place AE, Sandora TJ. Limiting Vancomycin Exposure in Pediatric Oncology Patients With Febrile Neutropenia May Be Associated With Decreased Vancomycin-Resistant Enterococcus Incidence. J Pediatric Infect Dis Soc. 2019 Oct 11. View abstract
  3. Ganapathi L, Blumenthal J, Alawdah L, Lewis L, Gilarde J, Jones S, Milliren C, Kim HB, Sharma TS. Impact of standardized protocols for cytomegalovirus disease prevention in pediatric solid organ transplant recipients. Pediatr Transplant. 2019 Nov; 23(7):e13568. View abstract
  4. Pajtler KW, Wei Y, Okonechnikov K, Silva PBG, Vouri M, Zhang L, Brabetz S, Sieber L, Gulley M, Mauermann M, Wedig T, Mack N, Imamura Kawasawa Y, Sharma T, Zuckermann M, Andreiuolo F, Holland E, Maass K, Körkel-Qu H, Liu HK, Sahm F, Capper D, Bunt J, Richards LJ, Jones DTW, Korshunov A, Chavez L, Lichter P, Hoshino M, Pfister SM, Kool M, Li W, Kawauchi D. YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis. Nat Commun. 2019 Sep 02; 10(1):3914. View abstract
  5. Hovestadt V, Smith KS, Bihannic L, Filbin MG, Shaw ML, Baumgartner A, DeWitt JC, Groves A, Mayr L, Weisman HR, Richman AR, Shore ME, Goumnerova L, Rosencrance C, Carter RA, Phoenix TN, Hadley JL, Tong Y, Houston J, Ashmun RA, DeCuypere M, Sharma T, Flasch D, Silkov A, Ligon KL, Pomeroy SL, Rivera MN, Rozenblatt-Rosen O, Rusert JM, Wechsler-Reya RJ, Li XN, Peyrl A, Gojo J, Kirchhofer D, Lötsch D, Czech T, Dorfer C, Haberler C, Geyeregger R, Halfmann A, Gawad C, Easton J, Pfister SM, Regev A, Gajjar A, Orr BA, Slavc I, Robinson GW, Bernstein BE, Suvà ML, Northcott PA. Resolving medulloblastoma cellular architecture by single-cell genomics. Nature. 2019 Aug; 572(7767):74-79. View abstract
  6. Kaul DR, Sharma TS. Human T-cell lymphotrophic virus in solid-organ transplant recipients: Guidelines from the American society of transplantation infectious diseases community of practice. Clin Transplant. 2019 Sep; 33(9):e13575. View abstract
  7. Sharma T, Schwalbe EC, Williamson D, Sill M, Hovestadt V, Mynarek M, Rutkowski S, Robinson GW, Gajjar A, Cavalli F, Ramaswamy V, Taylor MD, Lindsey JC, Hill RM, Jäger N, Korshunov A, Hicks D, Bailey S, Kool M, Chavez L, Northcott PA, Pfister SM, Clifford SC. Second-generation molecular subgrouping of medulloblastoma: an international meta-analysis of Group 3 and Group 4 subtypes. Acta Neuropathol. 2019 Aug; 138(2):309-326. View abstract
  8. Ocwieja KE, Vargas SO, Elisofon SA, Shulman DS, Lee CK, Fawaz R, Collins N, Vakili K, Sharma TS. Pediatric post-transplant hepatic kaposi sarcoma due to donor-derived human herpesvirus 8. Pediatr Transplant. 2019 05; 23(3):e13384. View abstract
  9. Sharma TS, Michaels MG, Danziger-Isakov L, Herold BC. Clinical Vignettes: Donor-Derived Infections. J Pediatric Infect Dis Soc. 2018 Dec 26; 7(suppl_2):S67-S71. View abstract
  10. Sharma TS, Michaels MG, Danziger-Isakov L, Herold BC. Clinical Vignettes: Donor-Derived Infections. J Pediatric Infect Dis Soc. 2018 Dec 26; 7(suppl_2):S67-S71. View abstract
  11. Sharma TS, Michaels MG, Danziger-Isakov L, Herold BC. Clinical Vignettes: Donor-Derived Infections. J Pediatric Infect Dis Soc. 2018 Dec 26; 7(suppl_2):S67-S71. View abstract
  12. Sharma TS, Michaels MG, Danziger-Isakov L, Herold BC. Clinical Vignettes: Donor-Derived Infections. J Pediatric Infect Dis Soc. 2018 Dec 26; 7(suppl_2):S67-S71. View abstract
  13. Sharma TS, Michaels MG, Danziger-Isakov L, Herold BC. Clinical Vignettes: Donor-Derived Infections. J Pediatric Infect Dis Soc. 2018 Dec 26; 7(suppl_2):S67-S71. View abstract
  14. Kumar D, Ferreira VH, Blumberg E, Silveira F, Cordero E, Perez-Romero P, Aydillo T, Danziger-Isakov L, Limaye AP, Carratala J, Munoz P, Montejo M, Lopez-Medrano F, Farinas MC, Gavalda J, Moreno A, Levi M, Fortun J, Torre-Cisneros J, Englund JA, Natori Y, Husain S, Reid G, Sharma TS, Humar A. A 5-Year Prospective Multicenter Evaluation of Influenza Infection in Transplant Recipients. Clin Infect Dis. 2018 10 15; 67(9):1322-1329. View abstract
  15. Sharma TS, Somarriba G, Arheart KL, Neri D, Mathew MS, Graham PL, Scott GB, Miller TL. Longitudinal Changes in Body Composition by Dual-energy Radiograph Absorptiometry Among Perinatally HIV-infected and HIV-uninfected Youth: Increased Risk of Adiposity Among HIV-infected Female Youth. Pediatr Infect Dis J. 2018 10; 37(10):1002-1007. View abstract
  16. Forget A, Martignetti L, Puget S, Calzone L, Brabetz S, Picard D, Montagud A, Liva S, Sta A, Dingli F, Arras G, Rivera J, Loew D, Besnard A, Lacombe J, Pagès M, Varlet P, Dufour C, Yu H, Mercier AL, Indersie E, Chivet A, Leboucher S, Sieber L, Beccaria K, Gombert M, Meyer FD, Qin N, Bartl J, Chavez L, Okonechnikov K, Sharma T, Thatikonda V, Bourdeaut F, Pouponnot C, Ramaswamy V, Korshunov A, Borkhardt A, Reifenberger G, Poullet P, Taylor MD, Kool M, Pfister SM, Kawauchi D, Barillot E, Remke M, Ayrault O. Aberrant ERBB4-SRC Signaling as a Hallmark of Group 4 Medulloblastoma Revealed by Integrative Phosphoproteomic Profiling. Cancer Cell. 2018 09 10; 34(3):379-395.e7. View abstract
  17. Cavalli FMG, Hübner JM, Sharma T, Luu B, Sill M, Zapotocky M, Mack SC, Witt H, Lin T, Shih DJH, Ho B, Santi M, Emery L, Hukin J, Dunham C, McLendon RE, Lipp ES, Gururangan S, Grossbach A, French P, Kros JM, van Veelen MC, Rao AAN, Giannini C, Leary S, Jung S, Faria CC, Mora J, Schüller U, Alonso MM, Chan JA, Klekner A, Chambless LB, Hwang EI, Massimino M, Eberhart CG, Karajannis MA, Lu B, Liau LM, Zollo M, Ferrucci V, Carlotti C, Tirapelli DPC, Tabori U, Bouffet E, Ryzhova M, Ellison DW, Merchant TE, Gilbert MR, Armstrong TS, Korshunov A, Pfister SM, Taylor MD, Aldape K, Pajtler KW, Kool M, Ramaswamy V. Heterogeneity within the PF-EPN-B ependymoma subgroup. Acta Neuropathol. 2018 08; 136(2):227-237. View abstract
  18. Geffner ME, Patel K, Jacobson DL, Wu J, Miller TL, Hazra R, Gerschenson M, Sharma T, Silio M, Jao J, Takemoto JK, Van Dyke RB, DiMeglio LA. Changes in insulin sensitivity over time and associated factors in HIV-infected adolescents. AIDS. 2018 03 13; 32(5):613-622. View abstract
  19. Korshunov A, Chavez L, Sharma T, Ryzhova M, Schrimpf D, Stichel D, Capper D, Sturm D, Kool M, Habel A, Kleinschmidt-DeMasters BK, Rosenblum M, Absalyamova O, Golanov A, Lichter P, Pfister SM, Jones DTW, Perry A, von Deimling A. Epithelioid glioblastomas stratify into established diagnostic subsets upon integrated molecular analysis. Brain Pathol. 2018 09; 28(5):656-662. View abstract
  20. Korshunov A, Chavez L, Northcott PA, Sharma T, Ryzhova M, Jones DTW, von Deimling A, Pfister SM, Kool M. DNA-methylation profiling discloses significant advantages over NanoString method for molecular classification of medulloblastoma. Acta Neuropathol. 2017 Dec; 134(6):965-967. View abstract
  21. Korshunov A, Schrimpf D, Ryzhova M, Sturm D, Chavez L, Hovestadt V, Sharma T, Habel A, Burford A, Jones C, Zheludkova O, Kumirova E, Kramm CM, Golanov A, Capper D, von Deimling A, Pfister SM, Jones DTW. H3-/IDH-wild type pediatric glioblastoma is comprised of molecularly and prognostically distinct subtypes with associated oncogenic drivers. Acta Neuropathol. 2017 Sep; 134(3):507-516. View abstract
  22. Wattier RL, Dvorak CC, Hoffman JA, Brozovich AA, Bin-Hussain I, Groll AH, Castagnola E, Knapp KM, Zaoutis TE, Gustafsson B, Sung L, Berman D, Halasa NB, Abzug MJ, Velegraki A, Sharma TS, Fisher BT, Steinbach WJ. A Prospective, International Cohort Study of Invasive Mold Infections in Children. J Pediatric Infect Dis Soc. 2015 Dec; 4(4):313-22. View abstract
  23. Youngster I, Sharma TS, Duncan CN, McAdam AJ. Yield of fungal surveillance cultures in pediatric hematopoietic stem cell transplant patients: a retrospective analysis and survey of current practice. Clin Infect Dis. 2014 Feb; 58(3):365-71. View abstract
  24. Sharma TS, Jacobson DL, Anderson L, Gerschenson M, Van Dyke RB, McFarland EJ, Miller TL. Short communication: The relationship between mitochondrial dysfunction and insulin resistance in HIV-infected children receiving antiretroviral therapy. AIDS Res Hum Retroviruses. 2013 Sep; 29(9):1211-7. View abstract
  25. Sharma N, Willen E, Garcia A, Sharma TS. Attitudes toward transitioning in youth with perinatally acquired HIV and their family caregivers. J Assoc Nurses AIDS Care. 2014 Mar-Apr; 25(2):168-75. View abstract
  26. Schwenk HT, Graham DA, Sharma TS, Sandora TJ. Vancomycin Use for Pediatric Clostridium difficile Infection Is Increasing and Associated with Specific Patient Characteristics. Antimicrob Agents Chemother. 2013 Sep; 57(9):4307-4313. View abstract
  27. Schwenk HT, Vo P, Moffitt K, Kehoe E, Blume E, Sharma T, Khatwa U. Allograft-Transmitted Histoplasma capsulatum Infection in a Solid Organ Transplant Recipient. J Pediatric Infect Dis Soc. 2013 Sep; 2(3):270-3. View abstract
  28. Sharma TS, Bechard LJ, Feldman HA, Venick R, Gura K, Gordon CM, Sonis A, Guinan EC, Duggan C. Effect of titrated parenteral nutrition on body composition after allogeneic hematopoietic stem cell transplantation in children: a double-blind, randomized, multicenter trial. Am J Clin Nutr. 2012 Feb; 95(2):342-51. View abstract
  29. Sharma TS, Hughes J, Murillo A, Riley J, Soares A, Little F, Mitchell CD, Hanekom WA. CD8+ T-cell interleukin-7 receptor alpha expression as a potential indicator of disease status in HIV-infected children. PLoS One. 2008; 3(12):e3986. View abstract
  30. Sharma TS, Kinnamon DD, Duggan C, Weinberg GA, Furuta L, Bechard L, Nicchitta J, Gorbach SL, Miller TL. Changes in macronutrient intake among HIV-infected children between 1995 and 2004. Am J Clin Nutr. 2008 Aug; 88(2):384-91. View abstract
  31. Miller TL, Grant YT, Almeida DN, Sharma T, Lipshultz SE. Cardiometabolic disease in human immunodeficiency virus-infected children. J Cardiometab Syndr. 2008; 3(2):98-105. View abstract
  32. Sharma TS, Messiah S, Fisher S, Miller TL, Lipshultz SE. Accelerated cardiovascular disease and myocardial infarction risk in patients with the human immunodeficiency virus. J Cardiometab Syndr. 2008; 3(2):93-7. View abstract