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Researcher | Research Overview

Dr. Edward Lee’s clinical expertise and innovations have been achieved by successfully combining his clinical research and teaching in the field of pediatric thoracic imaging to improve the ability of radiologists to non-invasively diagnose a variety of pediatric thoracic anomalies and abnormalities particularly with multidetector CT (MDCT) and magnetic resonance imaging (MRI). His role as the Chief of Thoracic Imaging Division and Director of MRI in the Departments of Radiology has provided him with the opportunity to develop a unique niche in the field of pediatric thoracic imaging - an area arguably underdeveloped both in terms of technologic innovation and patient therapies.

His primary research activities have focused on the development and application of advanced CT and MRI imaging methods, aimed at improving diagnostic capabilities, therapeutic options and patient outcomes in pediatric patients with various anomalies and abnormalities of the large airways, lungs and mediastinal vessels. Dr. Edward Lee has extensively researched MDCT in order to evaluate pediatric patients with congenital mediastinal vascular and lung anomalies with 2D and 3D imaging. His publications as a first author on this topic were among the first in the medical literature to scientifically evaluate the efficacy of this technique in diagnosing pediatric patients with congenital mediastinal vascular and lung anomalies. Dr. Edward Lee’s work helped to establish 2D and 3D imaging with MDCT as a standard of care for the imaging evaluation of children with various congenital mediastinal vascular and lung anomalies.

He has also developed and introduced a new MDCT technique, which has become the primary non-invasive imaging method to assess dynamic central airway diseases such as tracheobronchomalacia in infants and children  By showing that MDCT has comparable accuracy to bronchoscopy, this work has had an important clinical impact in both radiology and pulmonary medicine by obviating invasive procedures such as bronchoscopy in pediatric patients for assessing tracheobronchomalacia. He has written the techniques and guidelines related to the clinical use of dynamic MDCT for evaluating tracheobronchomalacia in infants and children.

Furthermore, Dr. Edward Lee is acknowledged as the first investigator to evaluate pulmonary embolism in pediatric patients with MDCT. His work on this topic has provided seminal information regarding direct and indirect CT imaging findings, role of 2D imaging for accurate diagnosis, and clinically valuable risk factor assessment for pulmonary embolism in pediatric patients, which helps facilitate prompt diagnosis and optimal patient care.

In addition to Dr. Lee’s work on MDCT, his current work is in testing the technical feasibility and clinical applicability of MRI using hyperpolarized gases (e.g., 3He) and innovative motion-robust-high-resolution MR technique to better visualize the central airways and lungs, which is supported by research grants from the Society for Pediatric Radiology (SPR), Association of University Radiologists and GE Health Care (GERRAF) and the Society of Thoracic Radiology (STR).

Researcher | Research Background

Dr. Edward Lee is an associate professor of radiology at Harvard Medical School. He received his A.B. and M.D. from the University of Chicago (Phi Beta Kappa and Swift Scholar) and his M.P.H. from Harvard University (Student Marshal), followed by an internship at Harvard Medical Center (BIDM / BWH / DFCI) and radiology residency at Mallincrodt Institute of Radiology / Washington University Medical Center. After completing a pediatric radiology fellowship as a chief fellow at Children’s Hospital Boston and Harvard Medical School in 2006, he joined the Departments of Radiology and Medicine, Division of Pulmonary Medicine as a clinician-researcher whose academic focus is on developing non-invasive imaging methods that will improve the clinical care of pediatric patients diagnosed with thoracic anomalies and abnormalities. Since Dr. Lee was appointed as the Chief of Thoracic Imaging Division in 2010 and Director of MRI in 2012, he has provided integrated image performance and interpretation across modalities for congenital and acquired pediatric thoracic disorders at Boston Children’s Hospital.

Dr. Lee has more than 110 peer-reviewed journal articles, 40 review articles or book chapters, and two books related to pediatric chest imaging.

He was the recipient of RSNA Eyler Editorial Fellowship in 2010. He is the winner of the prestigious Caffey’s Awards from SPR in both Best Clinical Scientific Research and Best Educational Exhibit Presentation categories. Additionally, as an assistant editor of the pediatric section of the American Journal of Roentgenology (AJR) and European Journal of Radiology (EJR); editorial board member of nine journals; and reviewer of 25 journals; Dr. Lee has also helped guide and establish the educational and scientific direction and growth in his academic specialty – pediatric thoracic imaging – at academic and medical institutions around the world.

Dr. Lee is currently one of the most sought-after internationally known pediatric radiology speakers in the field of pediatric thoracic imaging. He has served either as a visiting professor or as an invited speaker on various topics related to related to pediatric thoracic imaging education more than 20 different countries in the Americas, Europe, Middle East, Asia, and Africa.

His lecture topics include:

  1. Multidetector CT Evaluation of Congenital Lung Anomalies in Children

  2. Multidetector CT Evaluation of Central Airway Anomalies and Abnormalities in Pediatric Patients 

  3. Interstitial Lung Disease in Infants: New Classification, Imaging Findings and Pathological Correlation

  4. CT and MRI Evaluation of Mediastinal Vascular Anomalies in Children 

  5. CT Evaluation of Non-vascular Mediastinal Masses in Children: Step by Step Approach to Diagnosis 

  6. Chest Trauma in Children: Current Imaging Guidelines, Techniques, and Imaging Findings 

  7. Chest Sonography in Children: Practical Imaging Approach

  8. Imaging Evaluation of Chest Wall Lesions in Pediatric Patients

  9. Multimodality Imaging Evaluation of Pediatric Congenital Heart Disease 

  10. Interactive Pediatric Chest Cases

Researcher | Publications