Research

Research

The research enterprise at Boston Children’s Hospital, comprising more than 3,000 researchers, is the world’s largest at a pediatric center. Our work is fueled by a deep understanding of disease coupled with world-class discovery platforms, including genetics and genomics, gene editing, bioinformatics, proteomics, bioengineering, image analysis, multiple animal models, biobanks and disease-specific stem cell lines. We have special expertise in rare disease discovery and see large, highly diverse patient populations.

From ADHD to Zika virus, we partner closely with scientists worldwide. To accelerate translation of new therapies and technologies to the bedside, we partner with industry through such programs as the Technology and Innovation Development Office (TIDO), the Innovation & Digital Health Accelerator (IDHA) and the Translational Neuroscience Center.

Image of a mouse brain that received a direct transplantation of hematopoietic stem cells.

Gene therapy

Gene therapies offer powerful new options for addressing previously fatal or untreatable genetic diseases. Our investigators are at the forefront of pre-clinical research, vector development and clinical trials of gene therapies for a broad range of pediatric disorders.

Gene therapy news
blast cells in leukemia medical science concept

Pediatric cancer

Childhood cancers are driven by different genetic changes than adult cancers. Our scientists interrogate their complex origins with advanced genomic and drug screening techniques, and partner with clinical researchers to drive a new generation of pediatric cancer trials.

Cancer research news
Hands held in the shape of a brain, covered by EEG leads

Neuroscience

Understanding the nervous system at the genetic, molecular, cellular and systems level opens opportunities to tackle hard-to-treat disorders. From disease modeling in human neurons to clinical trials for genetic conditions, our basic and clinical scientists collaborate closely.

Neuroscience news

Genetics/Genomics

Next-generation DNA sequencing, chromosomal microarray, gene-expression studies, gene editing, genome-wide association studies and other tools are bringing fresh insights into the basic biology of disease, from common conditions like obesity to the exceedingly rare.

Genetics news
microscope image of b cell clones from the spleen

Immunology

New tools are fueling a burst of discoveries in immune deficiency, allergy, autoimmunity and inflammatory disease. We are learning new immunization strategies and how the immune system influences diseases not classically seen as immunologic, from neurodegenerative disorders to heart disease.

Immunology news
Alpha-type retinal ganglion cells (RGCs) in part of an intact mouse retina.

Regenerative medicine

Our labs are creating pluripotent stem cells for disease modeling and drug screening, investigating natural regenerative processes with cellular “barcodes,” and developing cell-based therapies and testing chemical factors that stimulate regeneration pathways.

Regenerative medicine news

Boston Children's Hospital Innovation

BCH Innovation News @BCH_Innovation 2/17/2019 6:00:01 PM
Ketamine, soon to be one of the first new #antidepressants in 30 years, may act differently during the… https://t.co/atPsG8FpOa
BCH Innovation News @BCH_Innovation 2/16/2019 3:59:38 PM
Ketamine should dull neural activity because it blocks a #glutamate receptor – yet it does the opposite, awakening… https://t.co/yh9BmfqSrx
BCH Innovation News @BCH_Innovation 2/15/2019 11:59:59 PM
Ketamine, soon to be one of the first new #antidepressants in 30 years, may act differently during the… https://t.co/vBb3hGnHLu
BCH Innovation News @BCH_Innovation 2/15/2019 10:14:36 PM
On Vector: How #ketamine relieves depression -- but variably in women: https://t.co/eG11hFdsA4 #psychiatry https://t.co/SZ6QZ7ct0Q
BCH Innovation News @BCH_Innovation 2/15/2019 7:54:51 PM
#Ketamine is nearing #FDA approval as an #antidepressant – and now we know how it works: https://t.co/TUVfU30Zsy https://t.co/Rl5JaicMvq
BCH Innovation News @BCH_Innovation 2/15/2019 4:29:35 PM
New research developed by scientists at @Harvard's Wyss Institute, Boston Children's, @MIT and NE Center for Stroke… https://t.co/KJ67qAjCpw
Boston Children's Hospital has been named the #1 children's hospital in the nation by U.S. News and World Report for the fifth year in a row! It's an honor that we could not have achieved without you. On behalf of every member of our Boston Children's team, thank you for inspiring us to be bolder, dream bigger, and make the impossible possible for our patients and families.

Sandra L. Fenwick, CEO

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