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Zhang Laboratory Research | Overview

 

Epigenetic modifications, particularly DNA methylation and covalent histone modifications, play an important role in regulating chromatin dynamics and therefore have a significant impact on gene expression.  The Zhang Lab has been interested in:

(1) how epigenetic modification-mediated dynamic changes in chromatin structure affect gene expression, embryonic development, cell lineage commitment, stem cell pluripotency/self-renewal

(2) epigenetic mechanism of drug addiction

(3) how dysregulation of epigenetic factors contributes to the development of diseases such as diabetes, neurological diseases, and cancer.

The long-term goal of the lab is to apply this basic research to studies of human diseases.